2009-05-01, English, Article, Report edition: A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.(Report) Anizon, Fabrice; Golsteyn, Roy M.; Leonce, StePhane; ...

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Physical Description
  • Report
  • Magazine/​Journal article
Published
  • Elsevier B.V., 2009 May
Language
  • English

Edition details

Title
  • A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.(Report)
Also Titled
  • A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor.
Appears In
  • European Journal of Medicinal Chemistry, v.44, no.5, 2009 May, p.2234(5) (ISSN: 0223-5234)
Author
  • Anizon, Fabrice
  • Golsteyn, Roy M.
  • Leonce, StePhane
  • Pfeiffer, Bruno
  • Prudhomme, Michelle
Published
  • Elsevier B.V., 2009 May
Physical Description
  • Report
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • To link to full-text access for this article, visit this link: http:/​/​dx.doi.org/​10.1016/​j.ejmech.2008.05.023 Byline: Fabrice Anizon (a), Roy M. Golsteyn (b), Stephane Leonce (b), Bruno Pfeiffer (b), Michelle Prudhomme (a) Abstract: Rebeccamycin derivative 1 bearing a sugar moiety linked to both indole nitrogens and an amino substituent on the carbohydrate unit was synthesized in three steps from the bacterial metabolite. This compound was found to be a highly potent checkpoint kinase 1 inhibitor with an IC.sub.50 value of 2.8nM. Author Affiliation: (a) Universite Blaise Pascal, Synthese et Etude de Systemes a Interet Biologique, UMR 6504 du CNRS, 63177 Aubiere, France (b) Institut de Recherches SERVIER, Division Recherche Cancerologie, 125 Chemin de ronde, 78290 Croissy sur Seine, France Article History: Received 10 January 2008; Revised 19 May 2008; Accepted 22 May 2008
Terms of Use
  • COPYRIGHT 2009 Elsevier B.V.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 350509970

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