2019, English, Thesis edition: Medicinal Chemistry & Chemical Biology Approaches to Investigate Prospective Treatments for CNS Diseases TIMOTHY JOHN FYFE

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Medicinal Chemistry & Chemical Biology Approaches to Investigate Prospective Treatments for CNS Diseases
 
Bookmark: https://trove.nla.gov.au/version/264046434
Physical Description
  • thesis (Doctor of Philosophy (Joint Award and Doctoral Training Centre with The University of Nottingham))
  • DOCTORATE
Published
  • Medicinal Chemistry, 2019
Language
  • English

Edition details

Title
  • Medicinal Chemistry &​ Chemical Biology Approaches to Investigate Prospective Treatments for CNS Diseases
Author
  • TIMOTHY JOHN FYFE
Other Contributors
  • Ben Capuano (Principal supervisor)
  • Professor Peter J. Scammells (Additional supervisor 1)
  • Dr J. Robert Lane (Additional supervisor 2)
  • Professor Barrie Kellam (Additional supervisor 3)
  • Dr Shailesh Mistry (Additional supervisor 4)
Published
  • Medicinal Chemistry, 2019
Physical Description
  • thesis (Doctor of Philosophy (Joint Award and Doctoral Training Centre with The University of Nottingham))
  • DOCTORATE
Subjects
Summary
  • Using techniques in Medicinal Chemistry and Chemical Biology, this thesis investigates novel prospective treatments for central nervous system disorders, namely schizophrenia and Parkinson’s disease. The dopamine receptors are heavily implicated in these diseases, and were the focus of this work. Small molecule allosteric modulators of these receptor systems interact with their receptor target in a unique way, and show promise as improved prospective treatments. As such, the identification of novel modulators that bind to this receptor system and the study of the way in which they influence chemical signalling was conducted through organic synthesis and molecular pharmacology studies.
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Language
  • English

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