2018-05-14, English, Article, Journal or magazine article edition: Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control cubjects via the enhancing neuro imaging genetics through meta analysis (ENIGMA) consortium van Erp, Theo G. M.; Walton, Esther; Hibar, Derrek P.; ...

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Physical Description
  • journal article
Published
  • Elsevier, 2018-05-14
Language
  • English

Edition details

Title
  • Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control cubjects via the enhancing neuro imaging genetics through meta analysis (ENIGMA) consortium
Author
  • van Erp, Theo G. M.
  • Walton, Esther
  • Hibar, Derrek P.
  • Schmaal, Lianne
  • Jiang, Wenhao
  • Glahn, David C.
  • Pearlson, Godfrey D.
  • Yao, Nailin
  • Fukunaga, Masaki
  • Hashimoto, Ryota
  • Okada, Naohiro
  • Yamamori, Hidenaga
  • Bustillo, Juan R.
  • Clark, Vincent P.
  • Agartz, Ingrid
  • Mueller, Bryon A.
  • Cahn, Wiepke
  • de Zwarte, Sonja M. C.
  • Hulshoff Pol, Hilleke E.
  • Kahn, René S.
  • Ophoff, Roel A.
  • van Haren, Neeltje E. M.
  • Andreassen, Ole A.
  • Dale, Anders M.
  • Doan, Nhat Trung
  • Gurholt, Tiril P.
  • Hartberg, Cecilie B.
  • Haukvik, Unn K.
  • Jørgensen, Kjetil N.
  • Lagerberg, Trine V.
  • Melle, Ingrid
Published
  • Elsevier, 2018-05-14
Physical Description
  • journal article
Subjects
Summary
  • BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. METHODS: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide. RESULTS: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/​right hemisphere: Cohen's d =​ -0.530/​-0.516) and smaller surface area (left/​right hemisphere: Cohen's d =​ -0.251/​-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. CONCLUSIONS: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.
Language
  • English
Related Resource
  • http:/​/​doi.org/​10.1016/​j.biopsych.2018.04.023
  • issn:1873-2402
  • issn:0006-3223
  • P20 GM103472
  • T32 MH019112
  • P50 MH064045
  • R01 EB015611
  • R01 MH056584
  • R37 MH043775
  • R01 EB005846
  • R01 MH094524
  • R01 EB006841
  • R01 MH060722
  • R01 MH101111
  • P41 RR014075
  • R01 DA027680
  • U01 MH108148
  • U54 EB020403
  • T32 MH067533
  • UL1 TR000153
  • P50 AA022534
  • U24 RR021992
  • K23 MH085096
  • P50 MH103222
  • R01 MH084803
  • UL1 RR025758
  • R01 MH112180
  • R01 GM061603
  • R01 MH058251
  • U24 RR025736
  • P50 MH071616
  • R01 MH074797
  • R01 MH085646
  • R01 MH107703
Identifier
  • oai:espace.library.uq.edu.au:UQ:1c47f1a

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