2006-02-01, English, Article, Journal or magazine article edition: Angiogenesis: The VE-Cadherin Switch. Wallez, Yann; Vilgrain, Isabelle; Huber, Philippe

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Bookmark: https://trove.nla.gov.au/version/92297583
Physical Description
  • Magazine/​Journal article
Published
  • Elsevier B.V., 2006 Feb
Language
  • English

Edition details

Title
  • Angiogenesis: The VE-Cadherin Switch.
Appears In
  • Trends in Cardiovascular Medicine, v.16, no.2, 2006 Feb, p.55(5) (ISSN: 1050-1738)
Author
  • Wallez, Yann
  • Vilgrain, Isabelle
  • Huber, Philippe
Published
  • Elsevier B.V., 2006 Feb
Physical Description
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • To link to full-text access for this article, visit this link: http:/​/​dx.doi.org/​10.1016/​j.tcm.2005.11.008 Byline: Yann Wallez, Isabelle Vilgrain, Philippe Huber Abstract: Because angiogenesis is a key step in a number of pathologic processes, including tumor growth and atherosclerosis, many research studies have investigated the regulatory signals active at various stages of vascular invasion. The differential activities of the endothelial junction protein vascular endothelial (VE)-cadherin reflect the versatile behavior of endothelial cells between vascular quiescence and angiogenesis. VE-cadherin function and signaling are deeply modified in proliferating cells, and this conversion is accompanied by phosphorylation of the protein on tyrosine residues and enhanced transcription of its gene. Recent advances in the complex interplay between protein tyrosine kinases and phosphatases regulating VE-cadherin phosphorylation and function are discussed in this review. Author Affiliation: Laboratoire de Developpement et Vieillissement de l'Endothelium, Universite Joseph Fourier, Grenoble, France Inserm, EMI 02-19, Grenoble, France CEA, Grenoble, France
Terms of Use
  • COPYRIGHT 2006 Elsevier B.V.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 197792469

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