2014-04-01, English, Article, Journal or magazine article edition: Inhibition of death receptor signaling by bacterial gut pathogens Giogha, C; Lung, TWF; Pearson, JS; ...

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Bookmark: https://trove.nla.gov.au/version/211167683
Physical Description
  • journal article
Published
  • ELSEVIER SCI LTD, 2014-04-01
Language
  • English

Edition details

Title
  • Inhibition of death receptor signaling by bacterial gut pathogens
Author
  • Giogha, C
  • Lung, TWF
  • Pearson, JS
  • Hartland, EL
Other Contributors
  • Hartland, Elizabeth L [0000-0003-4254-2863]
Published
  • ELSEVIER SCI LTD, 2014-04-01
Physical Description
  • journal article
Part Of
  • CYTOKINE &​ GROWTH FACTOR REVIEWS
Summary
  • Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.
Language
  • English
Related Resource
Identifier
  • oai:minerva-access.unimelb.edu.au:11343/​44188
  • oai:jupiter.its.unimelb.edu.au:11343/​44188

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