Experimental Pathology Unit. The Walter and Eliza Hall Institute of Medical Research. (1966-1982)

Also known as
The Walter and Eliza Hall Institute of Medical Research. Experimental Pathology Unit. (1966-1982)
Function
Medical Research
NLA Persistent Identifier
https://nla.gov.au/nla.party-1475655

Biographies

The Experimental Pathology Unit was created in April 1966, with the arrival of Dr J.F.A.P Miller from the Chester Beatty Research Institute. This Unit contained the Laboratory of Immunoparasitology until 1981. It was later taken over by the Infection and Immunity Division.

The Experimental Pathology Unit's main research interest was lymphocytes, particularly focusing on the role of the thymus in the immunological competencies of lymphocytes. The Unit compared populations in normal and thymectomised mice, examined proliferation and differentiation in response to antigen, and looked at precursor cells. Within four years of its existence, the Unit (Miller and Mitchell) demonstrated that thymus-derived lymphocytes or T-cells did not give rise to the cells that formed antibodies and that this instead was the function of bone marrow-derived lymphocytes, the B-cells.

In 1969 the Unit's research aims were targeted primarily at the function of thymus-derived cells and thymus-marrow interactions. Later, interests expanded to include studies of in vitro antibody response, immunological memory and the function of activated T-lymphocytes. One particular project in the early 1970s was the nature of the T-cell antigen receptor. They subsequently disproved ideas of a T-immunoglobulin comparable to the immunoglobulin receptor on B-cells. This lead into an increasing focus on the process of T-lymphocyte function and activation in response to antigen, and on the T-cell subset responsible for delayed type hypersensitivity (DTH) reactions. The Unit demonstrated that in DTH the triggering antigen must be associated with certain products of the major histocompatability complex (MHC) on the surface of macrophages. Between 1978 and 1981 the Unit began work on developing immortalised antigen-specific T-cell lines, invaluable in facilitating biochemical studies of T-cell differentiation, activation and function.

View the full record at Encyclopedia of Australian Science

Related people and organisations

Resources for Experimental Pathology Unit. The Walter and Eliza Hall Institute of Medical Research.

Selected resources (1)

Encyclopedia of Australian Science

  1. Experimental Pathology Unit
    Published: The University of Melbourne eScholarship Research Centre
    Series: Encyclopedia of Australian Science

No user comments for this organisation

Add a comment


Show comments and reviews from Amazon users

Possibly related

Digitised newspapers and more

Searching...

Minimise

Diaries, letters, archives

Searching...

Minimise

Archived websites (1996 – now)

view all results

  1. Snapshots of websites, web pages and online publications about Australia and Australians collected since 1996.

    Search archived websites
    Search

Pictures, photos, objects

Searching...

Minimise

Books

Searching...

Minimise

Music, sound and video

Searching...

Minimise

People and organisations

Searching...

Minimise

Journals, articles and data sets

Searching...

Minimise

Maps

Searching...

Minimise

Lists

Searching...

Minimise

Government Gazettes

Searching...

Minimise

Archived websites (1996 – now)

No results

Minimise
  1. Immunoparasitology Unit The Walter and Eliza Hall Institute of Medical Research (1981-1996)
    ... Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research (1996 - ) ... Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research ... consortium made up of the Hall Institute, the QLD Institute of Medical Research, the Commonwealth Serum ... (formally part of the Experimental Pathology Unit) and the Molecular Parasitology Laboratory. In 1985 the ...
    This resource is very relevant to your query (score: 4,613.62)

    This resource is very relevant to your query (score: 4,613.62)

  2. Thymus Biology Unit The Walter and Eliza Hall Institute of Medical Research (1981-1996)
    ... Experimental Pathology Unit, The Walter and Eliza Hall Institute of Medical Research (1966 - 1982) ... Immunology Division, The Walter and Eliza Hall Institute of Medical Research (1996 - ) ... In 1981/1982 the Thymus Biology Unit took over from the Experimental Pathology Unit. It was then ... Immunology Division. Research in the Thymus Biology Unit initially focused on cloning and characterising ...
    This resource is very relevant to your query (score: 3,816.656)

    This resource is very relevant to your query (score: 3,816.656)

  3. Infection and Immunity Division The Walter and Eliza Hall Institute of Medical Research (1996-)
    ... Experimental Pathology Unit, The Walter and Eliza Hall Institute of Medical Research (1966 - 1982) ... Immunoparasitology Unit, The Walter and Eliza Hall Institute of Medical Research (1981 - 1996) ... Papua New Guinea Institute of Medical Research, ran trials in PNG on another candidate malaria vaccine ... sulfa group of drugs. In 1999/2000 the Division began a new initiative, with the Biomolecular Research ...
    This resource is very relevant to your query (score: 3,625.066)

    This resource is very relevant to your query (score: 3,625.066)

  1. EXPERIMENTAL MEDICINE WALTER-ELIZA HALL GIFT.
    Morning Bulletin (Rockhampton, Qld. : 1878 - 1954) Saturday 25 August 1923 p 9 Article
    ... . H. Kellaway lae alj ready ta i.m over the control of th» Walter and Elira Hall Pathological In-stitute ... worked at the National % Institute of Medical Research on de- .J ficiency diseases, and subsequently with ... 507 words
    This resource is very relevant to your query (score: 6,159.062)

    This resource is very relevant to your query (score: 6,159.062)

  2. EXPERIMENTAL MEDICINE. WALTER AND ELIZA HALL GIFT. Institute's New Director[?]
    The Argus (Melbourne, Vic. : 1848 - 1957) Friday 17 August 1923 p 8 Article
    ... EXPERIMENTAL MEDICINE. WALTER AND ELIZA HALL GIFT. Institute's New Director, Although but recently ... returned to Mel-bourne, Dr C H. Kellaway has already taken n\cr tlio control of the Walter and Eliza Hall ... 489 words
    • Text last corrected on 19 March 2009 by kjharris
    This resource is very relevant to your query (score: 6,065.457)

    This resource is very relevant to your query (score: 6,065.457)

  3. Overseas research men for Canberra MEDICAL SCHOOL SOON
    Sunday Mail (Brisbane, Qld. : 1926 - 1954) Sunday 25 March 1951 p 2 Article
    ... Eliza Hall Institute, Melbourne. Professor J. C. Kccles. who has been appointed bead of the Chair of ... Curtin School of Medical Research. The school is now being established at Canberra as part of the ... 291 words
    This resource is very relevant to your query (score: 2,052.03)

    This resource is very relevant to your query (score: 2,052.03)

  1. AUSTRALIAN CAPITAL TERRITORY National Memorials Ordinance 1928 DETERMINATION
    Commonwealth of Australia Gazette. Periodic (National : 1977 - 2011) Friday 15 May 1987 p 1

    Government Gazette Proclamations And Legislation Illustrated

    ... research posts at the Walter and Eliza Hall Institute of Medical Research 1922-28 and at Lister Institute ... College of Physicians 1959; Walter and Eliza Hall medical research fellow 1959, senior research fellow ... 12629 words
    This resource is very relevant to your query (score: 915.497)

    This resource is very relevant to your query (score: 915.497)

  2. THE AUSTRALIA DAY 1997 HONOURS
    Commonwealth of Australia Gazette. Special (National : 1977 - 2012) Sunday 26 January 1997 p 1

    Government Gazette Appointments And Employment Illustrated

    ... research and the Howard Florey Institute of Experimental Physiology and Medicine, particularly in the field ... Sydney and the Australian Cancer Foundation for Medical Research. The Honourable George Henry WALTERS ... 14969 words
    This resource is very relevant to your query (score: 187.11)

    This resource is very relevant to your query (score: 187.11)

  3. AUSTRALIA DAY 2002 HONOURS
    Commonwealth of Australia Gazette. Special (National : 1977 - 2012) Saturday 26 January 2002 p 1

    Government Gazette Notices Illustrated

    ... contributor to the financial administration of public hospitals and medical research institutes conducted by ... sustainable aquaculture industries, to environmental research and protection, and to the progress of ... 16730 words
    This resource is very relevant to your query (score: 15.525)

    This resource is very relevant to your query (score: 15.525)

Pictures, photos, objects

No results

Minimise

Lists

No results

Minimise

Maps

No results

Minimise
  1. Non-invasive assessment of the efficacy of new therapeutics for intestinal pathologies using serial endoscopic imaging of live mice
    Ernst, Matthias; Preaudet, Adele; Putoczki, Tracy; The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia; The Depar ...
    Journal of Visualized Experiments; 2015; (97): e52383
    [ Article : 2015 ]
    View online
    At Austin Health DSpace
    Non-invasive assessment of the efficacy of new therapeutics for intestinal pathologies using serial endoscopic imaging of live mice
    This resource is very relevant to your query (score: 53.003)

    This resource is very relevant to your query (score: 53.003)

  2. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling
    Schmidt, Stefanie; Schumacher, Neele; Schwarz, Jeanette; Tangermann, Simone; Kenner, Lukas; Schlederer, Michaela; Sibilia, Maria; Linder, Markus; Alte ...
    The Journal of experimental medicine 2018; 215(4): 1205-1225
    [ Article : 2018 ]
    View online (access conditions)
    At Austin Health DSpace
    This resource is very relevant to your query (score: 41.41)

    This resource is very relevant to your query (score: 41.41)

  3. TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
    Etemadi, Nima; Chopin, Michael; Anderton, Holly; Tanzer, Maria C; Rickard, James A; Abeysekera, Waruni; Hall, Cathrine; Spall, Sukhdeep K; Wang, Bing; ...
    eLife 2015-12-23; 4
    [ Article : 2015 ]
    View online (access conditions)
    At Austin Health DSpace
    This resource is very relevant to your query (score: 38.725)

    This resource is very relevant to your query (score: 38.725)

  4. Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2
    Corbett, Mark A; Kroes, Thessa; Veneziano, Liana; Bennett, Mark F; Florian, Rahel; Schneider, Amy L; Coppola, Antonietta; Licchetta, Laura; Francesche ...
    Nature communications 2019; 10(1): 4920
    [ Article : 2019 ]
    View online (access conditions)
    At Austin Health DSpace
    This resource is very relevant to your query (score: 31.078)

    This resource is very relevant to your query (score: 31.078)

  1. PP no. 66 of 1982, Part 1
    Australian Science and Technology Council
    Medical research in Australia, November 1981
    [ Book : 1982 ]
    View online
    At Trove DigitalLibrary
    PP no. 66 of 1982, Part 1
    This resource may be of limited relevance to your query (score: 0.158)

    This resource may be of limited relevance to your query (score: 0.158)

  2. PP no. 67 of 1982, Part 2
    Australian Science and Technology Council
    Medical research in Australia, November 1981
    [ Book : 1982 ]
    View online
    At Trove DigitalLibrary
    PP no. 67 of 1982, Part 2
    This resource may be of limited relevance to your query (score: 0.156)

    This resource may be of limited relevance to your query (score: 0.156)

  3. Psychosocial and Ethical Issues Related to Congenital Heart Disease: From the Foetus to the Adult - A Tribute to the Mothers of Affected Offspring
    SAMUEL MENAHEM
    [ Thesis : 2019 ]
    View online
    At Monash Online
    Psychosocial and Ethical Issues Related to Congenital Heart Disease: From the Foetus to the Adult - A Tribute to the Mothers of Affected Offspring
    This resource may be of limited relevance to your query (score: 0.114)

    This resource may be of limited relevance to your query (score: 0.114)

  4. The role of Fas and TNFα in experimental autoimmune gastritis / Aiden Christopher James Marshall
    Marshall, Aiden Christopher James, 1976-
    [ Thesis : 2003 ]
    View online
    At 2 libraries
    The role of Fas and TNFα in experimental autoimmune gastritis / Aiden Christopher James Marshall
    This resource may be of limited relevance to your query (score: 0.1)

    This resource may be of limited relevance to your query (score: 0.1)

  1. Catherine Helen Spence
    Spence, Catherine Helen, 1825-1910
    [ Unpublished : 1866-1910 ]
    View online (access conditions)
    At State Library S Aust
    This resource may be of limited relevance to your query (score: 0.12)

    This resource may be of limited relevance to your query (score: 0.12)

  2. J.B. Cleland
    Cleland, J.B. Sir, (John Burton), 1878-1971
    [ Unpublished : 1889 ]
    At State Library S Aust
    This resource may be of limited relevance to your query (score: 0.11)

    This resource may be of limited relevance to your query (score: 0.11)

  1. Stem Cell Research
    Australian Broadcasting Corporation. Radio National
    [ Sound : 1998-2015 ]
    View online
    At ABC Radio National
    Stem Cell Research
    This resource is very relevant to your query (score: 36.821)

    This resource is very relevant to your query (score: 36.821)

  2. Malaria Vaccine
    Australian Broadcasting Corporation. Radio National
    [ Sound : 1997-2002 ]
    View online
    At ABC Radio National
    Malaria Vaccine
    This resource may be of limited relevance to your query (score: 0.247)

    This resource may be of limited relevance to your query (score: 0.247)

  3. Professor Jacques Miller Interview (Vh)
    Australian Academy of Science
    [ Video : 1999 ]
    This resource may be of limited relevance to your query (score: 0.153)

    This resource may be of limited relevance to your query (score: 0.153)

  4. Full transcript
    Australian Broadcasting Corporation. Radio National
    [ Sound : 2000-2015 ]
    View online
    At ABC Radio National
    Full transcript
    This resource may only be vaguely related to your query: matching terms may only have been found in the full text contents of the resource (score: 0.07)

    This resource may only be vaguely related to your query: matching terms may only have been found in the full text contents of the resource (score: 0.07)