English, Article edition: The Work Productivity and Activity Impairment Questionnaire for Patients with Gastroesophageal Reflux Disease (WPAI-GERD): Responsiveness to Change and English Language Validation Peter Wahlqvist; Gordon H. Guyatt; David Armstrong; ...

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Bookmark: http://trove.nla.gov.au/version/95116
Physical Description
  • article
Language
  • English

Edition details

Title
  • The Work Productivity and Activity Impairment Questionnaire for Patients with Gastroesophageal Reflux Disease (WPAI-GERD): Responsiveness to Change and English Language Validation
Author
  • Peter Wahlqvist
  • Gordon H. Guyatt
  • David Armstrong
  • Alessio Degl'Innocenti
  • Diane Heels-Ansdell
  • Samer El-Dika
  • Ingela Wiklund
  • Carlo A. Fallone
  • Lisa Tanser
  • Sander Veldhuyzen van Zanten
  • Peggy Austin
  • Alan N. Barkun
  • Naoki Chiba
  • Holger J. Schunemann
Physical Description
  • article
Notes
  • Background: A validated productivity questionnaire, the Work Productivity and Activity Impairment questionnaire for Gastroesophageal Reflux Disease (WPAI-GERD), exists for Swedish patients with GERD. Objective: To assess responsiveness to change of the WPAI-GERD and construct validity of the English language version. Methods: We used the WPAI-GERD in a before-after treatment clinical study of Canadian GERD patients with moderate or severe symptoms treated with esomeprazole 40mg once daily for 4 weeks. We measured productivity variables including GERD-specific absence from work, reduced productivity while at work and reduced productivity while carrying out regular daily activities other than work during the preceding week. Results: The analysis included 217 patients, of whom 71% (n_=​_153) were employed. Before treatment, employed patients reported an average 0.9 hours of absence from work due to GERD and 14.0% reduced work productivity (5.8 hours equivalent) in the previous week, as well as 21.0% reduced productivity in daily activities (all patients). After treatment, the corresponding figures decreased to 0.3 hours, 3.0% (1.1 hours equivalent) and 4.9%, respectively. Thus, the improvement (difference from start of treatment) in productivity was 0.6 hours (p_=​_0.011) for absence from work and 11.0% units (p_<_0.001) for reduced work productivity (4.7 hours equivalent, p_<_0.001). This translated into an avoided loss of work productivity of 5.3 hours in total on a weekly basis per employed patient. In addition, a 16.1% unit (p_<_0.001) improvement for reduced productivity in activities was observed. Cross-sectional correlation coefficients of WPAI variables with symptoms (range 0.04-0.63) and health-related quality of life (HR-QOL; range 0.02-0.65) supported cross-sectional construct validity. Corresponding change score correlations between WPAI variables and HR-QOL (range 0.05-0.56) supported longitudinal construct validity of the WPAI-GERD while low change score correlations between productivity variables and relevant symptoms (range 0.06-0.34) did not. Conclusion: The English version of the WPAI-GERD showed good cross-sectional construct validity, and results indicated that the WPAI-GERD is responsive to change. Although the results also indicated that longitudinal construct validity may be poor, the overall findings suggest that further study of the instrument remains warranted.
  • Coronary-disorders, Gastro-oesophageal-reflux, Pharmaceutical-services, Randomised-controlled-trials
  • RePEc:wkh:phecon:v:25:y:2007:i:5:p:385-396
Language
  • English
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