English, Article edition: Economic Analysis of Filgrastim Use for Patients with Acute Myeloid Leukaemia in the UK: A Comparison of Collection Methods of Resource Use Data Bo Standaert; Janet Goldstone; Z. John Lu; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/95006
Physical Description
  • article
Language
  • English

Edition details

Title
  • Economic Analysis of Filgrastim Use for Patients with Acute Myeloid Leukaemia in the UK: A Comparison of Collection Methods of Resource Use Data
Author
  • Bo Standaert
  • Janet Goldstone
  • Z. John Lu
  • Moshe Haim Erder
  • John Liu Yin
Physical Description
  • article
Notes
  • Background: A clinical trial of patients with de novo acute myeloid leukaemia (AML) showed that haematopoietic support with filgrastim (granulocyte colony-stimulating factor, G-CSF) following induction and consolidation chemotherapy accelerated recovery from neutropenia. The clinical benefits included reductions in infections, anti-infective therapy and length of hospital stay. Objective: The objective of this economic analysis is 2-fold. First, it aims to determine if the observed clinical benefits from the use of filgrastim would lead to cost savings from the perspective of a healthcare institution in the UK. Second, the analysis compares the results of two methods on collection of resource use data. Design: A retrospective cost-minimisation analysis was undertaken based on the clinical results of all UK patients enrolled in the trial. Two cost models were developed: a model based only on the medical resource use collected in the case report forms (the CRF model); and a model based on all medical resources collected from patient medical files (the PF Model). Treatment costs of AML between filgrastim and the placebo arm were compared for the first induction cycle as well as the first induction and the first consolidation cycles combined. Results from the two models were compared. Setting and Patients: The CRF model was applied to two samples of patients: all UK patients (n =​ 82) and patients enrolled at one centre [the Manchester Royal Infirmary (MRI) (n =​ 30)], whereas the PF model was applied to the MRI patient sample only. Results: For all UK patients, using the CRF model, the filgrastim-treated arm produced cost savings of Lstg 747 (9.0%) and Lstg 2135 (14.4%) [1998 values] per patient in the first induction cycle and in the induction and consolidation cycles combined, respectively. For the patients at MRI the CRF model resulted in cost savings with filgrastim of Lstg 177 (2.2%) and Lstg 414 (3.2%) per patient respectively. Using the PF model the savings at MRI were Lstg 910 (8.6%) and Lstg 1285 (8.0%) per patient, respectively. Conclusion: Use of filgrastim in the treatment of AML in the UK may result in net cost savings. A retrospective analysis using total resources obtained through patient files produced higher cost savings estimates than that obtained by resources noted in the CRFs. The models based on PF resource data may be more reliable because they are more comprehensive. However, the cost estimates in this study may have been impacted by sample size, site characteristics, disease and treatment settings. Therefore, further evaluation on the methods for collecting resource use data in larger, multicentred studies is warranted.
  • Cost analysis, Filgrastim, Granulocyte colony stimulating factors, Neutropenia, Pharmacoeconomics
  • RePEc:wkh:phecon:v:20:y:2002:i:10:p:665-674
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment