English, Article edition: Cost Analysis of the Treatment of Schizophrenia in the UK: A Simulation Model Comparing Olanzapine, Risperidone and Haloperidol Stephen Almond; Owen O'Donnell

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Physical Description
  • article
Language
  • English

Edition details

Title
  • Cost Analysis of the Treatment of Schizophrenia in the UK: A Simulation Model Comparing Olanzapine, Risperidone and Haloperidol
Author
  • Stephen Almond
  • Owen O'Donnell
Physical Description
  • article
Notes
  • Objective: To compare the costs of 2 atypical drug therapies (olanzapine and risperidone) with one another and with a conventional antipsychotic (haloperidol) in the treatment of schizophrenia. Design and setting: The analysis is based on a simulation model with parameter values taken mainly from clinical trial data in patients with schizophrenia, and was conducted within a UK context. Results: The 3 therapies are approximately cost neutral over a 5-year period (olanzapine Lstg 35 701, risperidone Lstg 36 590 and haloperidol Lstg 36 653). There is evidence of greater efficacy with the atypical drugs [average percentage of 5 years with Brief Psychiatric Rating Scale (BPRS) scores <18: olanzapine 63.6%, risperidone 63.0% and haloperidol 52.2%]. The cost and efficacy differences between the 2 atypical drugs are too small to rank them in terms of cost effectiveness. Extensive sensitivity analysis does not change any of the main conclusions. Conclusions: Given evidence of efficacy gains to the atypical drugs, these represent cost-effective treatment options. Prospective data from nontrial treatment settings would help substantiate the model findings.
  • Cost analysis, Haloperidol, Neuropsychotherapeutics, Olanzapine, Pharmacoeconomics, Risperidone, Schizophrenia
  • RePEc:wkh:phecon:v:17:y:2000:i:4:p:383-389
Language
  • English
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