English, Article edition: An Economic Evaluation of Rizatriptan in the Treatment of Migraine Melissa Thompson; Marek Gawel; Brigitte Desjardins; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/94759
Physical Description
  • article
Language
  • English

Edition details

Title
  • An Economic Evaluation of Rizatriptan in the Treatment of Migraine
Author
  • Melissa Thompson
  • Marek Gawel
  • Brigitte Desjardins
  • Nicole Ferko
  • Daniel Grima
Physical Description
  • article
Notes
  • Background: Migraine is a common, chronic, neurovascular disorder, generally characterised by attacks of severe headache and autonomic nervous system dysfunction. Triptans are selective serotonin 5-HT1B/​1D receptor agonists that represent effective therapeutic options for moderate-to-severe migraine attacks but with higher acquisition costs relative to usual care therapies. Objective: The objective of this study was to examine the cost effectiveness of rizatriptan treatment compared with `Usual Care' or other triptans available in Canada for patients with moderate-to-severe migraine for whom other therapies (e.g. NSAIDs, simple analgesics) are insufficient or contraindicated. Methods: A decision-analysis model was created to estimate migraine treatment costs over a 24-hour period in patients with a diagnosis of moderate-to-severe migraine as defined by the International Headache Society criteria. Costs and clinical outcomes were observed over a 24-hour period from therapy initiation. Efficacy measures consisted of `pain-free response at 2 hours' and `sustained pain free for 2-24 hours'. Oral rizatriptan 10mg was compared with other oral triptans (i.e. sumatriptan 50 or 100mg), naratriptan 2.5mg and zolmitriptan 2.5mg, based on a meta-analysis and compared with `Usual Care' based on a naturalistic study of people who experience migraine and who were similar to the target population. `Usual Care' was defined as an aggregate of medications prescribed for the Canadian population for the indication of migraine, weighted by the relative frequency of use of prescriptions over a 1-year period. Analyses were conducted from the Ontario (Canada) Ministry of Health and Long-Term Care (MOH&​LTC) perspective and the broader societal perspective. Results are presented as the cost per migraine attack aborted (i.e. pain free at 2 hours), as well as the cost per QALY. Several one-way sensitivity analyses were conducted to test the robustness of the model. All costs are expressed in 2002 $Can. Results: Cost estimates are similar to previously published Canadian studies. Rizatriptan compared with `Usual Care' produced an incremental cost per attack aborted of $Can49.82 and a cost per QALY gained of $Can31_845 from the MOH&​LTC perspective. When a societal perspective was considered (which included time loss from paid and unpaid work activities), rizatriptan dominates `Usual Care': that is, it is cost saving and more effective. All other triptans are also dominated by rizatriptan as they offer higher costs and lower efficacy. Conclusions: This study shows that rizatriptan treatment for patients who experience moderate-to-severe migraines may represent a cost-effective strategy for improving care of migraine patients in Canada.
  • Cost-utility, Migraine, Naratriptan, Rizatriptan, Serotonin-receptor-agonists, Sumatriptan, Zolmitriptan
  • RePEc:wkh:phecon:v:23:y:2005:i:8:p:837-850
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment