English, Article edition: HIV-1 Drug Resistance Genotyping: A Review of Clinical and Economic Issues Carine Chaix-Couturier; Christopher Holtzer; Kathryn A. Phillips; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/94724
Physical Description
  • article
Language
  • English

Edition details

Title
  • HIV-1 Drug Resistance Genotyping: A Review of Clinical and Economic Issues
Author
  • Carine Chaix-Couturier
  • Christopher Holtzer
  • Kathryn A. Phillips
  • Isabelle Durand-Zaleski
  • John Stansell
Physical Description
  • article
Notes
  • The development of mutations associated with resistance to antiretroviral therapy (ART) has been shown to be a major cause of treatment failure in patients infected with HIV-1. These resistance mutations can be assessed by a genotyping test that probes for specific mutations within the HIV genome or sequences specific genes, at a cost $US500/​test (2000 prices). The stated goal of HIV-1 genotyping is to target HIV therapy effectively. This, as shown in the preliminary research, should result in better clinical outcomes and a lower incidence of virological failure and may be associated with lower costs of treatment. Failure of ART may result in an increase in costs of at least $US250 per patient per month, as assessed in 1 study, with costs rising further as patients experience multiple virological failures. Therefore, there is an economic as well as a therapeutic premium on the prevention of ART failure. The actual economic cost of genotyping has been preliminarily explored in the context of the antiretroVIRal ADAPTation (VIRADAPT) trial, which found no significant difference in the 1-year treatment cost of patients with and without genotyping. There is some evidence of cost neutrality or savings with genotypic testing but it needs to be further explored within the context of carefully framed prospective trials.
  • Antimicrobial resistance, Antivirals, Cost analysis, HIV 1 infections, Pharmacoeconomics
  • RePEc:wkh:phecon:v:18:y:2000:i:5:p:425-433
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment