English, Article edition: Comparing the Cost Effectiveness of Risperidone and Olanzapine in the Treatment of Schizophrenia Using the Net-Benefit Regression Approach Annemieke De Ridder; Diana De Graeve

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Physical Description
  • article
Language
  • English

Edition details

Title
  • Comparing the Cost Effectiveness of Risperidone and Olanzapine in the Treatment of Schizophrenia Using the Net-Benefit Regression Approach
Author
  • Annemieke De Ridder
  • Diana De Graeve
Physical Description
  • article
Notes
  • Objective: To estimate the cost effectiveness of olanzapine and risperidone for the treatment of schizophrenia in Belgium. Methods: Data were retrieved from a prospective, observational, non-randomized, follow-up survey. Clinical investigators assigned 265 patients with schizophrenia to either olanzapine (n - 136) or risperidone (n - 129). Patients were followed up for 2 years. Total healthcare costs were determined from the public payer perspective and calculated by multiplying resource use with official tariffs; effectiveness of the drugs was measured with the EQ-5D. This study uses a net-benefit regression approach to accommodate for baseline differences between treatment groups and uncertainty. Results: Total 2-year costs were very similar for patients receiving risperidone and olanzapine (€20 915.33 and €20 569.69, respectively; p - 0.925) &​lsqb;year 2002 values&​rsqb;. The health condition of the patients receiving risperidone was better than that of patients receiving olanzapine but not significantly so (1.46 and 1.41, respectively; p - 0.191). Simple ordinary least squares (OLS) regressions indicated that, for λ - €40 000, we could not reject the null hypothesis that the drugs provide similar net monetary benefits to the patient (risperidone vs olanzapine €2046.95; p - 0.656). When we controlled for several patient characteristics, risperidone moved further away from olanzapine but the difference did not reach statistical significance (risperidone vs olanzapine €3198.07; p - 0.595). Numerous sensitivity analyses confirmed the robustness of the results. Conclusion: Results of this study suggest that it is important to control for baseline patient characteristics when performing a cost-effectiveness analysis. No significant difference in net monetary benefit was found between risperidone and olanzapine.
  • RePEc:wkh:phecon:v:27:y:2009:i:1:p:69-80
Language
  • English
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