English, Article edition: Economic Assessment of Adjustable Maintenance Treatment with Budesonide/Formoterol in a Single Inhaler versus Fixed Treatment in Asthma Bernd Bruggenjurgen; Dagmar Selim; Peter Kardos; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/94350
Physical Description
  • article
Language
  • English

Edition details

Title
  • Economic Assessment of Adjustable Maintenance Treatment with Budesonide/​Formoterol in a Single Inhaler versus Fixed Treatment in Asthma
Author
  • Bernd Bruggenjurgen
  • Dagmar Selim
  • Peter Kardos
  • Kai Richter
  • Claus Vogelmeier
  • Stephanie Roll
  • Wolfgang Meyer-Sabellek
  • Roland Buhl
  • Stefan N Willich
Physical Description
  • article
Notes
  • Objectives: To compare the costs and effectiveness of adjustable maintenance dosing with budesonide/​formoterol in a single inhaler versus fixed dosing in adults with asthma. Methods: In this prospective, randomised, open-label, parallel-group, multicentre trial conducted in Germany, patients with asthma received budesonide/​formoterol 160mug/​4.5mug in a single inhaler (Symbicort(R) Turbuhaler(R)) with two inhalations twice daily for a 4-week run-in period. Patients were then randomised to either adjustable maintenance dosing (one inhalation twice daily, stepping up to four inhalations twice daily for 1 week if asthma worsened; n =​ 1679) or fixed dosing (two inhalations twice daily; n =​ 1618) for 12 weeks. The primary efficacy variable was the change in health-related quality of life (HR-QOL), measured using the Asthma Quality of Life Questionnaire (standardised) during the randomised treatment period. Resource utilisation data were collected in parallel and combined with German unit costs to estimate direct and indirect costs (year 2001 values). Results: Both treatment regimens were equally effective in maintaining HR-QOL and asthma control during the randomised treatment period. However, overall, patients in the adjustable maintenance dosing group took fewer daily inhalations of budesonide/​formoterol than those in the fixed-dosing group (mean: 2.63 vs 3.82 inhalations; p < 0.001). Adjustable maintenance dosing was associated with significantly lower asthma-related direct costs compared with fixed dosing (mean: _221 vs _292; p < 0.001). This pattern was maintained when patients were stratified into those with peak expiratory flow (PEF) of 60% to <80% predicted normal and those with PEF of >=​80% predicted normal and when total costs were considered. Conclusion: Adjustable maintenance dosing with budesonide/​formoterol in a single inhaler maintained HR-QOL in adult patients with asthma at a significantly lower cost than fixed dosing.
  • Asthma, Bronchodilators, Budesonide, Corticosteroids, Cost-minimisation, Formoterol, Randomised-controlled-trials
  • RePEc:wkh:phecon:v:23:y:2005:i:7:p:723-731
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment