English, Article edition: Varicella Vaccination in Italy: An Economic Evaluation of Different Scenarios Laurent Coudeville; Alain Brunot; Carlo Giaquinto; ...

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Bookmark: http://trove.nla.gov.au/version/94095
Physical Description
  • article
Language
  • English

Edition details

Title
  • Varicella Vaccination in Italy: An Economic Evaluation of Different Scenarios
Author
  • Laurent Coudeville
  • Alain Brunot
  • Carlo Giaquinto
  • Carlo Lucioni
  • Benoit Dervaux
Physical Description
  • article
Notes
  • Aim: To determine the economic impact (cost-benefit analysis) of childhood varicella vaccination, with the Oka/​Merck varicella zoster virus vaccine live (Varivax(R)) in Italy. Methods: This analysis is based on an epidemiological model of varicella zoster virus (VZV) dynamics adapted to the Italian situation. Cost data ( Perspectives: A societal perspective, including both direct and indirect costs, and a health-system perspective, limited to costs supported by Italian Health Authorities, were considered. Results: A routine vaccination programme has a clearly positive impact on chickenpox morbidity. Respectively, 68% and 57% of chickenpox-related hospitalisations and deaths could be prevented with a 90% coverage rate. With vaccination costs being more than offset by a reduction in chickenpox treatment costs in the base case, such a programme could also induce savings from both a societal and a health-system perspective (40% and 12% savings, respectively for a 90% coverage rate). A lower coverage rate reduces cost savings, but there is still a 9% decrease in overall societal costs for a 45% coverage rate. Although the reduction in total societal costs was robust to the sensitivity analyses performed, a slight uncertainty remains regarding cost reduction from a health-system perspective. However, in this latter perspective, even in the worst-case scenario of the sensitivity analysis, routine vaccination programmes may be cost effective, the worst-case scenario for cost parameters leading to cost per life-year gained of Conclusion: This model suggests, with its underlying assumptions and data, that routine VZV vaccination may be cost saving from both a societal and a health system perspective in the base case. In the worst-case scenario of the sensitivity analysis, vaccination remains cost effective.
  • Chickenpox, Children, Cost-benefit, Varicella-zoster-virus-vaccine-live
  • RePEc:wkh:phecon:v:22:y:2004:i:13:p:839-855
Language
  • English
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