English, Article edition: An Economic Evaluation of Fluvastatin used for the Prevention of Cardiac Events Following Successful First Percutaneous Coronary Intervention in the UK Paul A. Scuffham; Stephen Chaplin

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Bookmark: http://trove.nla.gov.au/version/94065
Physical Description
  • article
Language
  • English

Edition details

Title
  • An Economic Evaluation of Fluvastatin used for the Prevention of Cardiac Events Following Successful First Percutaneous Coronary Intervention in the UK
Author
  • Paul A. Scuffham
  • Stephen Chaplin
Physical Description
  • article
Notes
  • Aims: To estimate the costs, benefits and cost effectiveness, from the UK NHS perspective, of fluvastatin (relative to no HMG-CoA reductase inhibitor [statin]) for the secondary prevention of major adverse cardiac events following a successful first percutaneous coronary intervention (PCI). Methods: A cost-effectiveness analysis was undertaken using efficacy data from the Lescol(R) Intervention Prevention Study (LIPS). LIPS was a randomised, double-blind, placebo-controlled trial undertaken in 77 centres (predominantly in Europe). Patients included in the trial had moderate hypercholesterolaemia and had successfully undergone their first PCI. Fluvastatin (Lescol(R)) 40mg twice daily plus dietary counselling was given to the intervention group for up to 4 years; the control group received dietary counselling only. A Markov model was used to estimate the incremental costs per QALY gained over a 10-year period, with cost data drawn from the UK NHS (2002 values). Monte Carlo simulations and multivariate analysis were used to assess uncertainty. Costs were discounted at 6% per annum, and health outcomes at 1.5% per annum. Results: On average, treatment with fluvastatin cost an additional Lstg 300 (SD Lstg 303) [ Conclusions: Fluvastatin is the only statin which has proven effective in preventing major coronary adverse events in new PCI patients; other statins lack this evidence. This Markov model, with its underlying assumptions and data, suggests that fluvastatin is a viable and economically efficient pharmaceutical (relative to no statin) to reduce heart disease in the UK when given routinely to all patients following PCI.
  • Angioplasty, Atherosclerosis, Cost-effectiveness, Fluvastatin, Heart-disorders, HMG-CoA-reductase-inhibitors
  • RePEc:wkh:phecon:v:22:y:2004:i:8:p:525-535
Language
  • English
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