English, Article edition: Can Sequential Administration Minimise the Cost of High Dose Chemotherapy?: An Economic Assessment in Inflammatory Breast Cancer Patricia Marino; Anne-Gaelle Le Corroller; Thao Palangie; ...

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Bookmark: http://trove.nla.gov.au/version/93966
Physical Description
  • article
Language
  • English

Edition details

Title
  • Can Sequential Administration Minimise the Cost of High Dose Chemotherapy?: An Economic Assessment in Inflammatory Breast Cancer
Author
  • Patricia Marino
  • Anne-Gaelle Le Corroller
  • Thao Palangie
  • Maud Janvier
  • Michel Fabbro
  • Laurent Molinier
  • Thierry Delozier
  • Alain Livartowski
  • Jean-Paul Moatti
  • Patrice Viens
Physical Description
  • article
Notes
  • Objective: To evaluate the potential cost savings of using sequential high dose chemotherapy (HDC), with granulocyte colony-stimulating factor (filgrastim) and stem cell support, rather than single course administration of HDC with bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT). Perspective: French public hospital perspective. Methods: Direct medical costs of sequential treatment, estimated on the basis of physical quantities of resources consumed by 95 patients with inflammatory breast cancer (IBC) included in a French pilot multicentric trial (PEGASE 02), were compared with those of historical control groups of patients treated with single course HDC, either with BMT (n =​ 27) or PBSCT (n =​ 14). Costs were evaluated in 1998 French francs (1 Results: The total cost of sequential HDC was significantly lower than that for single course HDC both with BMT (-29%; Conclusion: According to our results, economic arguments cannot be used against the widespread use of sequential HDC for patients with IBC. However, further economic evaluations based on overall and disease-free survivals alongside a randomised clinical trial are still needed to definitively establish the cost effectiveness of sequential administration of HDC.
  • Antineoplastics, Bone-marrow-transplant, Breast-cancer, Cisplatin, Cost-analysis, Cyclophosphamide, Doxorubicin, Etoposide, Mitoxantrone, Melphalan, Pharmacoeconomics, Fluorouracil, Filgrastim, Granulocyte-colony-stimulating-factors, Stem-cell-transplant
  • RePEc:wkh:phecon:v:21:y:2003:i:11:p:807-818
Language
  • English
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