English, Article edition: The Cost Effectiveness of Chlorofluorocarbon-Free Beclomethasone Dipropionate in the Treatment of Chronic Asthma: A Cost Model Based on a 1-Year Pragmatic, Randomised Clinical Study David Price; John Haughney; Martin Duerden; ...

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Bookmark: http://trove.nla.gov.au/version/93848
Physical Description
  • article
Language
  • English

Edition details

Title
  • The Cost Effectiveness of Chlorofluorocarbon-Free Beclomethasone Dipropionate in the Treatment of Chronic Asthma: A Cost Model Based on a 1-Year Pragmatic, Randomised Clinical Study
Author
  • David Price
  • John Haughney
  • Martin Duerden
  • Charles Nicholls
  • Charlotte Moseley
Physical Description
  • article
Notes
  • Objective: To compare the cost effectiveness of hydrofluoroalkane 134a-beclomethasone dipropionate (HFA-BDP; Qvar(TM)) with chlorofluorocarbon-beclomethasone dipropionate (CFC-BDP) in patients with chronic stable asthma previously receiving CFC-BDP, from the perspective of a healthcare provider. Design: Cost-effectiveness analysis based on a 12-month pragmatic, randomised, parallel group, open-label clinical trial assessing safety and efficacy of HFA-BDP at approximately half the dose of CFC-BDP in patients with stable asthma. Setting: International, multicentre study at 57 study sites in the US, UK, The Netherlands, and Belgium. Healthcare costs were calculated for UK-based healthcare [in 1999 as pounds (Lstg )]. Patients and Participants: Patients (n =​ 473) >=​12 years of age with currently stable asthma that had been stable (i.e. no exacerbations requiring oral corticosteroid use in the last 4 weeks) for at least the preceding month. Main Outcome Measures: Average and incremental cost-effectiveness ratios based upon symptom-free days, improvement in health-related quality of life, and total and drug-only direct healthcare costs. Results: Patients in the HFA-BDP group experienced a significantly higher percentage of symptom-free days than patients in the CFC-BDP group by the end of the study period (42.4 vs 20.0%; p =​ 0.006). A greater percentage of patients in the HFA-BDP group had a clinically significant improvement in health-related quality of life than in the CFC-BDP group [35.3 (n =​ 116/​329) vs 16.1% (n =​ 18/​112)]. Total per patient healthcare costs were similar between the two groups. The average cost per symptom-free day per patient was Lstg 1.36 for HFA-BDP and Lstg 1.81 for CFC-BDP based on total healthcare costs. The incremental cost per symptom-free day for using HFA-BDP instead of CFC-BDP was negative, indicating that HFA-BDP is a dominant strategy and may be a cost-saving intervention compared with CFC-BDP. A sensitivity analysis varying both cost and outcome parameters further supported this finding for most scenarios tested. The cost to achieve a clinically significant improvement in health-related quality of life over the study period was Lstg 13.24 per improved patient per week for HFA-BDP and Lstg 29.38 per patient per week for CFC-BDP. Conclusions: These findings indicate that HFA-BDP is a cost-effective intervention when compared with CFC-BDP in this group of patients with stable asthma. In the majority of scenarios HFA-BDP provides more effective asthma control at a similar cost to CFC-BDP.
  • Antiasthmatics, Asthma, Beclomethasone, Cost effectiveness, Pharmacoeconomics
  • RePEc:wkh:phecon:v:20:y:2002:i:10:p:653-664
Language
  • English
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