English, Article edition: A Comparative Review of Health-Related Quality-of-Life Measures for Use in HIV/AIDS Clinical Trials Darren J. Clayson; Diane J. Wild; Paul Quarterman; ...

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Physical Description
  • article
Language
  • English

Edition details

Title
  • A Comparative Review of Health-Related Quality-of-Life Measures for Use in HIV/​AIDS Clinical Trials
Author
  • Darren J. Clayson
  • Diane J. Wild
  • Paul Quarterman
  • Isabelle Duprat-Lomon
  • Maria Kubin
  • Stephen Joel Coons
Physical Description
  • article
Notes
  • With the advent of highly active antiretroviral therapy (HAART), HIV-infected patients are living longer and are concerned not only with a treatment's ability to extend their life but also with the quality of the life they are able to lead. Regulatory authorities are also paying closer attention to the use of health-related quality-of-life (HR-QOL) measures in clinical trials and to the subsequent claims that are made based on the results. This paper reviews existing HR-QOL measures reported in the HIV/​AIDS literature since 1990 and identifies those most worthy of consideration for use in future clinical trials. A comprehensive review following predefined selection criteria was conducted. Generic and HIV-targeted measures were assessed for content and practicality for the clinical trial setting. The generic measures were additionally reviewed for the ability to produce preference-based index scores and for the existence of normative general population data. Three generic and six HIV-targeted measures met these selection criteria and were then assessed more fully in terms of their development (HIV-targeted measures), psychometric properties and appropriateness for use in clinical trials. It was determined that each of the selected generic measures (i.e. Medical Outcomes Study [MOS] 36-Item Short Form Survey Instrument [SF-36], EQ-5D, Health Utilities Index [HUI]) could serve as a useful adjunct to an HIV-targeted measure in a trial. The Functional Assessment of HIV Infection (FAHI) and MOS-HIV health survey were deemed the two most appropriate HIV-targeted measures. Each of the measures can be self-administered in <=​10 minutes and there was ample evidence of their excellent psychometric properties. However, they would not be optimal in all HIV-infected subgroups (e.g. treatment naive vs advanced; adolescents vs older adults) targeted for clinical trial interventions. Although there is no one best HR-QOL measure for use in HIV/​AIDS clinical trials, based on our review criteria we identified three generic and two HIV-targeted candidate measures. However, these measures have their limitations and it is clear that greater consensus needs to develop regarding more effective and efficient approaches to HR-QOL measurement in HIV/​AIDS clinical trials. Along with the increasingly complex HR-QOL measurement task resulting from changes in the HIV-infected population and shifts in the HR-QOL burden associated with HIV infection and its treatment over the past 25 years, it is increasingly important that HR-QOL outcomes become viable endpoints in HIV/​AIDS clinical trials.
  • Acquired-immunodeficiency-syndrome, Clinical-trial-design, HIV-infections, Quality-of-life-rating-scales
  • RePEc:wkh:phecon:v:24:y:2006:i:8:p:751-765
Language
  • English
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