English, Article edition: Economic Assessment of the Secondary Prevention of Ischaemic Events with Lysine Acetylsalicylate Jean-Pierre Marissal; Bernard Selke; Therese Lebrun

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/93556
Physical Description
  • article
Language
  • English

Edition details

Title
  • Economic Assessment of the Secondary Prevention of Ischaemic Events with Lysine Acetylsalicylate
Author
  • Jean-Pierre Marissal
  • Bernard Selke
  • Therese Lebrun
Physical Description
  • article
Notes
  • Objective: to analyse the economic benefits, in comparison with placebo, of the secondary prevention of ischaemic stroke and myocardial infarction (MI) with lysine acetylsalicylate (Kardegic(R)) in patients with a history of ischaemic stroke, MI or stable and unstable angina pectoris. Design and setting: This was a modelling study from the perspectives of direct medical costs, the social security system and society in France. Methods: Efficacy data for the secondary prevention of ischaemic events were derived from the Antiplatelet Trialists' Collaboration meta-analysis on antithrombotics. The rates and costs of ischaemic disease and of serious gastrointestinal adverse affects arising from long term aspirin treatment, as well as the costs of treatment with lysine acetylsalicylate, were taken from published sources, using French data where possible. Results: From the social security perspective, the estimated cost-effectiveness ratios show that the prevention of MI in patients with a history of unstable angina (with a 1-year follow-up) is a cost-saving strategy, with net benefits ranging from $US5703 (1996 prices) per avoided MI for lysine acetylsalicylate 300 mg/​day to $US5761 per avoided MI for lysine acetylsalicylate 75 mg/​day. The prevention of MI and stroke is also a cost-saving strategy in patients with prior MI [net benefits in a 2-year follow-up (5% discount rate) ranging from $US15 to $US494 per avoided MI and from $US37 to $US1170 per avoided stroke]. This was also true in patients with prior ischaemic stroke (net benefits in a 3-year follow-up ranging from $US610 to $US2082 per avoided MI and from $US176 to $US599 per avoided stroke). Finally, a 4-year follow-up in patients with a history of stable angina pectoris shows that prophylactic treatment with lysine acetylsalicylate is associated with net costs per avoided MI, ranging from $US4375 to $US3608 per avoided event. Sensitivity analysis confirmed that prophylaxis with lysine acetylsalicylate in patients at high risk of cardiovascular and cerebrovascular events results in savings in social security expenditure. Conclusions: Our results underline the high economic benefit of using lysine acetylsalicylate to prevent secondary ischaemic stroke and MI in patients at high risk of cardiovascular and/​or cerebrovascular events, leading to savings for the social security system and society.
  • Antiplatelets, Cost effectiveness, Lysine acetylsalicylate, Myocardial infarction, Myocardial infarction, Pharmacoeconomics, Stroke, Stroke
  • RePEc:wkh:phecon:v:18:y:2000:i:2:p:185-200
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment