ELECTROCHEMICAL BEHAVIORS OF MATRINE AT L-CYSTEINE-MODIFIED ELECTRODES
Matrine is an important natural occurring component in sophora roots. It has a wide range of pharmacological actions. In this work, electrochemical investigation of matrine and its interaction with L-cysteine (L-Cys) is reported. Via the electrochemical approach, we have proved that the distribution coefficients of protonated and deprotonated matrine affect its electrochemical response on Au or L-Cys modified Au electrodes. The study by ultraviolet spectroscopy also finds that the molecular interaction between matrine and L-Cys changes with the distribution coefficients of protonated and deprotonated matrine at different pH value. Compared with the response of matrine on the bare gold electrode, the L-Cys/Au self-assembled monolayers modified electrodes exhibit obviously higher current response toward matrine oxidation. The oxidation current of matrine at L-Cys assembled electrode has a good linear relation in the range of 0.2â5 mM, with the correlation coefficient of 0.989 by cyclic voltammagrams. Electrochemical combined with spectroscopic techniques would provide relatively easy way to better understand the underlying mechanism of matrine/L-Cys interaction and will be helpful for the development of electroanalytical techniques for the determination of matrine.
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