2009-07-16, English, Article, Report edition: Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS).(Research)(Report) Murdoch, David M.; Suchard, Melinda S.; Venter, Willem DF.; ...

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Physical Description
  • 5764 words
  • Report
  • Magazine/​Journal article
Published
  • BioMed Central Ltd., 2009 July 16
Language
  • English

Edition details

Title
  • Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS).(Research)(Report)
Also Titled
  • Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS).
Appears In
  • AIDS Research and Therapy, v.6, 2009 July 16, p.16 (ISSN: 1742-6405)
Author
  • Murdoch, David M.
  • Suchard, Melinda S.
  • Venter, Willem DF.
  • Mhlangu, Patrick
  • Ottinger, Janet S.
  • Feldman, Charles
  • Van Rie, Annelies
  • Glencross, Deborah K.
  • Stevens, Wendy S.
  • Weinhold, Kent J.
Published
  • BioMed Central Ltd., 2009 July 16
Physical Description
  • 5764 words
  • Report
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • Objective To immunophenotype CD4.sup.+ .sup.and CD8.sup.+ .sup.T cell sub-populations in HIV-associated immune reconstitution inflammatory syndrome (IRIS). Design Nested case-control immunological study. Methods ART-na#239;ve HIV-infected patients were prospectively observed for IRIS during the first 6 months of ART. Twenty-two IRIS cases and 22 ART-duration matched controls were sampled for T cell immunophenotyping. Results IRIS cases demonstrated significantly lower CD4 cell counts compared to controls (baseline: 79 versus 142, p =​ 0.02; enrollment: 183 versus 263, p =​ 0.05, respectively) with no differences in HIV RNA levels. Within CD4.sup.+.sup.T cells, cases exhibited more of an effector memory phenotype compared to controls (40.8 versus 27.0%, p =​ 0.20), while controls trended towards a central memory phenotype (43.8 versus 30.8%, p =​ 0.07). Within CD8.sup.+ .sup.T cells, controls exhibited more central memory (13.9 versus 7.81%, p =​ 0.01, respectively) and effector (13.2 versus 8.8%, p =​ 0.04, respectively) phenotypes compared to cases, whereas cases demonstrated more terminal effectors than controls (28.8 versus 15.1%, p =​ 0.05). Cases demonstrated increased activation of CD8.sup.+ .sup.T cell effector memory, terminal effector, and effector subsets than controls (p =​ 0.04, 0.02, and 0.02, respectively). Conclusion CD4.sup.+ .sup.and CD8.sup.+ .sup.T cell subset maturational phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases demonstrated significant increases in activation of CD8.sup.+ .sup.T cell effector subpopulations.
Terms of Use
  • COPYRIGHT 2009 BioMed Central Ltd.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 205300756

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