2008-09-04, English, Article, Journal or magazine article edition: A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study.(Research article) Novelli, Flavia; Milella, Michele; Melucci, Elisa; ...

User activity

Send to:
 
Bookmark: http://trove.nla.gov.au/version/85572812
Physical Description
  • 7423 words
  • Magazine/​Journal article
Published
  • BioMed Central Ltd., 2008 Sept 4
Language
  • English

Edition details

Title
  • A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study.(Research article)
Also Titled
  • A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study.
Appears In
  • Breast Cancer Research (Online Edition), v.10, no.R74, 2008 Sept 4, p.R74 (ISSN: 1465-542X)
Author
  • Novelli, Flavia
  • Milella, Michele
  • Melucci, Elisa
  • Di Benedetto, Anna
  • Sperduti, Isabella
  • Perrone-Donnorso, Raffaele
  • Perracchio, Letizia
  • Venturo, Irene
  • Nistico, Cecilia
  • Fabi, Alessandra
  • Buglioni, Simonetta
  • Natali, Pier Giorgio
  • Mottolese, Marcella
Published
  • BioMed Central Ltd., 2008 Sept 4
Physical Description
  • 7423 words
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • Introduction Estrogen receptor-alpha (ER-[alpha]) and progesterone receptor (PgR) are consolidated predictors of response to hormonal therapy (HT). In contrast, little information regarding the role of estrogen receptor-beta (ER-[beta]) in various breast cancer risk groups treated with different therapeutic regimens is available. In particular, there are no data concerning ER-[beta] distribution within the novel molecular breast cancer subtypes luminal A (LA) and luminal B (LB), HER2 (HS), and triple-negative (TN). Methods We conducted an observational prospective study using immunohistochemistry to evaluate ER-[beta] expression in 936 breast carcinomas. Associations with conventional biopathological factors and with molecular subtypes were analyzed by multiple correspondence analysis (MCA), while univariate and multivariate Cox regression analysis and classification and regression tree analysis were applied to determine the impact of ER-[beta] on disease-free survival in the 728 patients with complete follow-up data. Results ER-[beta] evenly distributes (55.5%) across the four molecular breast cancer subtypes, confirming the lack of correlation between ER-[beta] and classical prognosticators. However, the relationships among the biopathological factors, analyzed by MCA, showed that ER-[beta] positivity is located in the quadrant containing more aggressive phenotypes such as HER2 and TN or ER-[alpha]/​PgR/​Bcl2.sup.- .sup.tumors. Kaplan-Meier curves and Cox regression analysis identified ER-[beta] as a significant discriminating factor for disease-free survival both in the node-negative LA (P =​ 0.02) subgroup, where it is predictive of response to HT, and in the node-positive LB (P =​ 0.04) group, where, in association with PgR negativity, it conveys a higher risk of relapse. Conclusion Our data indicated that, in contrast to node-negative patients, in node-positive breast cancer patients, ER-[beta] positivity appears to be a biomarker related to a more aggressive clinical course. In this context, further investigations are necessary to better assess the role of the different ER-[beta] isophorms.
Terms of Use
  • COPYRIGHT 2008 BioMed Central Ltd.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 185404800

Get this edition

Via a library membership

Library View online via
Australian Bureau of Statistics. Castles Library.
Australian College of Physical Education. Australian College of Physical Education Library.
Australian Catholic University. Alumni Access.
Australian Catholic University. Electronic Resources.
Australian Institute of Professional Education.
Australian School of Tourism and Hotel Management.
Avondale College. Avondale College Sydney Campus Library.
Blue Mountains International Hotel Management School.
Bond University. John and Alison Kearney Library .
Campion College Australia.
Charles Darwin University. Casuarina Campus Library.
Cengage Education.
Christian Heritage College. Christian Heritage College Library.
Deakin University. Deakin University Library.
Department for Manufacturing, Innovation, Trade, Resources & Energy. DMITRE Geoscience Library.
Edith Cowan University. Edith Cowan University Library.
Australian College of Natural Medicine Pty Ltd. Endeavour College of Natural Health Library.
Kaplan Professional. Library.
NSW Fire Brigades. FRNSW Library.
University of Notre Dame Australia. Galvin Medical Library.
Holmesglen Institute of TAFE. Holmesglen Learning Commons.
International College of Management, Sydney. ICMS Library.
Australian Lutheran College. Lohe Memorial Library.
Macquarie University. Macquarie University Library.
Marcus Oldham Farm Management College. Sir James Darling Resource Centre.
Melbourne Library Service.
Monash University. Monash University Library.
Moore Theological College. Moore Theological College Library.
SA Mental Health Services.
Sydney Missionary and Bible College. J.T.H. Kerr Library.
South Western Sydney Institute of TAFE.
Swinburne University of Technology. Swinburne Library.
Tabor Adelaide. Tabor Adelaide Library.
Tabor College Victoria.
The Southport School. Senior Library.
Think: Education Group. Think Education Group Learning Resource Centre.
University of New England. Dixson Library.
University of Canberra. University of Canberra Library.
University of Wollongong. University of Wollongong Library.
University of Queensland. University of Queensland Library. UQ Library Cyberschool.
University of Western Sydney. Penrith Campus, Ward Library.
Catholic Institute of Sydney. Veech Library.
University of Adelaide. Waite Library.
Wesley Institute for Ministry and the Arts. Wesley Institute Library.
Show 0 more libraries...
Library View online via
Australian Bureau of Statistics. Castles Library.
University of Canberra. University of Canberra Library.
Show 0 more libraries...
Library View online via
Australian College of Physical Education. Australian College of Physical Education Library.
Australian Catholic University. Alumni Access.
Australian Catholic University. Electronic Resources.
Australian Institute of Professional Education.
Avondale College. Avondale College Sydney Campus Library.
Blue Mountains International Hotel Management School.
Campion College Australia.
Cengage Education.
Kaplan Professional. Library.
NSW Fire Brigades. FRNSW Library.
International College of Management, Sydney. ICMS Library.
Macquarie University. Macquarie University Library.
Moore Theological College. Moore Theological College Library.
Sydney Missionary and Bible College. J.T.H. Kerr Library.
South Western Sydney Institute of TAFE.
Think: Education Group. Think Education Group Learning Resource Centre.
University of New England. Dixson Library.
University of Wollongong. University of Wollongong Library.
University of Western Sydney. Penrith Campus, Ward Library.
Catholic Institute of Sydney. Veech Library.
Wesley Institute for Ministry and the Arts. Wesley Institute Library.
Show 0 more libraries...
Library View online via
Charles Darwin University. Casuarina Campus Library.
Show 0 more libraries...
Library View online via
Bond University. John and Alison Kearney Library .
Christian Heritage College. Christian Heritage College Library.
Australian College of Natural Medicine Pty Ltd. Endeavour College of Natural Health Library.
The Southport School. Senior Library.
University of Queensland. University of Queensland Library. UQ Library Cyberschool.
Show 0 more libraries...
Library View online via
Department for Manufacturing, Innovation, Trade, Resources & Energy. DMITRE Geoscience Library.
Australian Lutheran College. Lohe Memorial Library.
SA Mental Health Services.
Tabor Adelaide. Tabor Adelaide Library.
University of Adelaide. Waite Library.
Show 0 more libraries...
Library View online via
Deakin University. Deakin University Library.
Holmesglen Institute of TAFE. Holmesglen Learning Commons.
Marcus Oldham Farm Management College. Sir James Darling Resource Centre.
Melbourne Library Service.
Monash University. Monash University Library.
Swinburne University of Technology. Swinburne Library.
Tabor College Victoria.
Show 0 more libraries...

Published in

Some editions of the publication "Breast cancer research (Online)" are available from these libraries. The edition containing this article ( v.10, no.R74, 2008 Sept 4, p.R74 ) may not be available:

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (4)
  • QLD (1)
  • SA (1)
  • VIC (2)
None of your libraries hold this item.

These 4 locations in All:

Library Access Call number(s) Formats held Language
CSIRO. Library Services. Not open to the public 314621; Online access. Available for document delivery. Restrictions apply.; Vol. 1 (1999)- Periodical; Journal, magazine, other English
Flinders University. Flinders University Central Library. Open to the public 977161; Web; ELECTRONIC FORMAT; Available on the INTERNET (coverage may vary at publisher's discretion)1999- Periodical; Journal, magazine, other English
Griffith University. Griffith University Library. Open to the public .b14795231; Electronic Resource : Publ. may restrict Doc. Del. Periodical; Journal, magazine, other English
Peter MacCallum Cancer Institute. Central Cancer Library. Open to the public v.1-; 1999- Periodical; Journal, magazine, other English
Show 0 more libraries...
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

This single location in Queensland:

Library Access Call number(s) Formats held Language
Griffith University. Griffith University Library. Open to the public .b14795231; Electronic Resource : Publ. may restrict Doc. Del. Periodical; Journal, magazine, other English
Show 0 more libraries...

This single location in South Australia:

Library Access Call number(s) Formats held Language
Flinders University. Flinders University Central Library. Open to the public 977161; Web; ELECTRONIC FORMAT; Available on the INTERNET (coverage may vary at publisher's discretion)1999- Periodical; Journal, magazine, other English
Show 0 more libraries...
None of your libraries hold this item.

These 2 locations in Victoria:

Library Access Call number(s) Formats held Language
CSIRO. Library Services. Not open to the public 314621; Online access. Available for document delivery. Restrictions apply.; Vol. 1 (1999)- Periodical; Journal, magazine, other English
Peter MacCallum Cancer Institute. Central Cancer Library. Open to the public v.1-; 1999- Periodical; Journal, magazine, other English
Show 0 more libraries...
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment