Inglés, Article edition: Acta Farmacéutica Bonaerense; vol. 23, no. 1; Estimation of the aqueous solubility of some acetanilide derivatives from octanol-water partition coefficients and entropies of fusion Baena, Yolima; Barbosa, Helber J.; Pinzón, Jorge A.; ...

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  • Artículo
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  • Se.Di.C.I. - Servicio de Difusion de la Creacion Intelectual UNLP
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  • Inglés

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Title
  • Acta Farmacéutica Bonaerense; vol. 23, no. 1; Estimation of the aqueous solubility of some acetanilide derivatives from octanol-water partition coefficients and entropies of fusion
Author
  • Baena, Yolima
  • Barbosa, Helber J.
  • Pinzón, Jorge A.
  • Martínez, Fleming
Published
  • Se.Di.C.I. - Servicio de Difusion de la Creacion Intelectual UNLP
Physical Description
  • text/​html
  • Artículo
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Notes
  • Se utilizaron algunas ecuaciones empíricas desarrolladas por Yalkowsky et al. para la estimación de la solubilidad en medios acuosos (SW), del acetaminofén, la fenacetina y la acetanilida, utilizando valores experimentales de coeficiente de reparto (PC) y, de temperaturas (tm) y entropías de fusión (?Sf). Las solubilidades calculadas fueron comparadas con las determinadas experimentalmente, encontrando buena concordancia para la acetanilida y la fenacetina en la mayoría de los casos, mientras que para el acetaminofén ningún modelo ofrece resultados confiables.
Language
  • Inglés
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