English, Article edition: Analysis of microtubule dynamics using growth curve models S. Rao Jammalamadaka; Md. Aleemuddin Siddiqi; Kaushik Ghosh

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Bookmark: http://trove.nla.gov.au/version/50334
Physical Description
  • article
Language
  • English

Edition details

Title
  • Analysis of microtubule dynamics using growth curve models
Author
  • S. Rao Jammalamadaka
  • Md. Aleemuddin Siddiqi
  • Kaushik Ghosh
Physical Description
  • article
Notes
  • Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics.
  • growth curves, microtubule dynamics, polynomial regression, splines, MANOVA, Wilks' Lamda,
  • RePEc:taf:japsta:v:36:y:2009:i:6:p:621-631
Language
  • English
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