2006, 2004, English, Article, Journal or magazine article edition: Structural and functional consequences of glutamine tract variation in the androgen receptor Buchanan, G.; Yang, M.; Cheong, A.; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/49356793
Physical Description
  • journal article
Published
  • Oxford Univ Press, 2006-06-26T03:00:49Z 2004
Language
  • English

Edition details

Title
  • Structural and functional consequences of glutamine tract variation in the androgen receptor
Author
  • Buchanan, G.
  • Yang, M.
  • Cheong, A.
  • Harris, J.
  • Irvine, R.
  • Lambert, P.
  • Moore, N.
  • Raynor, M.
  • Neufing, P.
  • Coetzee, G.
  • Tilley, W.
Published
  • Oxford Univ Press, 2006-06-26T03:00:49Z 2004
Physical Description
  • journal article
Subjects
Summary
  • © 2004 Oxford University Press
  • Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analyzed genome-wide data for 168 schizophrenia families using neuropsychological variables associated with disease susceptibility, with the aid of SOLAR, a program for variancecomponent analysis. The linkage signal was greatly accentuated by application of the quantitative traits compared with diagnosis. We found evidence for a locus for verbal learning and memory on 4q21 (Z 5 3.01, Zmp 5 3.84 and empiric P 5 0.031 for delayed memory; Z 5 2.96, Zmp 5 3.4 and P 5 0.026 for verbal learning) and suggestive evidence for visual working memory on 2q36 (Z 5 2.80, Zmp 5 2.08 and P 5 0.093). In addition, some evidence emerged for a locus for recognition memory on 10p13, visual attention on 15q22 and executive function on 9p22 in the complete sample, as well as for delayed memory on 8q12, semantic clustering and intrusions on 1q42 and visual attention on 3p25 in the genealogically distinctive sample subsets. Of the loci linked to schizophrenia in diverse populations, in addition to the earlier mentioned regions, some evidence of linkage was observed for 2q, 6q, 7q, 11q, 13q, 14q, 18q and 22q. Our results reveal initial information on the effect of the loci associated with schizophrenia in multiple studies, and emphasize the value of trait components in the search for susceptibility loci for complex diseases.
  • Grant Buchanan, Miao Yang, Albert Cheong, Jonathan M. Harris, Ryan A. Irvine, Paul F. Lambert, Nicole L. Moore, Michael Raynor, Petra J. Neufing, Gerhard A. Coetzee and Wayne D. Tilley
Language
  • English
Related Resource
Identifier
  • oai:digital.library.adelaide.edu.au:2440/​9500
  • Human Molecular Genetics, 2004; 13(16):1677-1692
  • 0964-6906
  • 1460-2083
  • 0020041811
  • 10.1093/​hmg/​ddh181
  • 000222880700001
  • 2-s2.0-4444288439
  • 56023

Get this edition

Published in

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • SA (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

This single location in South Australia:

Library Access Call number(s) Formats held Language
University of Adelaide. Barr Smith Library. University of Adelaide: Institutional Repository. Open to the public Article; Journal or magazine article English
Show 0 more libraries...
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment