2004, English, Article, Journal or magazine article, Video edition: Uroflow in murine urethritis

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Bookmark: http://trove.nla.gov.au/version/5376130
Physical Description
  • 57261434 bytes, 146412 bytes, video/​quicktime, application/​pdf
  • Preprint
Published
  • 2004-05-19T19:08:23Z
Language
  • English

Edition details

Title
  • Uroflow in murine urethritis
Other Authors
  • Leung, Yuk-Yuen Max
  • Schwarz, Edward M.
  • Silvers, Christopher R.
  • Messing, Edward M.
  • Wood, Ronald W.
Published
  • 2004-05-19T19:08:23Z
Physical Description
  • 57261434 bytes, 146412 bytes, video/​quicktime, application/​pdf
  • Preprint
Subjects
Notes
  • Method for measuring uroflow and void duration in the mouse
  • Objective: Genetically engineered mice may improve understanding of a variety of human bladder diseases. We developed a non-invasive method to measure urinary flow rate in the mouse. This could be useful for the study of bladder outlet obstruction as well as processes affecting detrusor function in the awake animal. Methods: A metabolic cage without a fecal separation screen was placed above a precision balance that reported the mass of the excreta pan every 100 msec. A computational algorithm identified voids suitable for assessment of uroflow from other excretory events. These algorithms were verified by comparison with series of images obtained automatically before and during excretory events. Intraurethral acetic acid was used to induce urethritis and to verify the sensitivity of the measurement technique. Results: Automatic categorization and characterization of uroflow was successful. Brief exposures of the urethra of the female C57BL6/​J mouse to 2% acetic acid decreased uroflow and increased void duration without a change in void volume. Conclusions: This method will enable studies of urologic function in mice of differing age, sex, strain, and genetic constitution. Murine urethritis can be differentiated from cystitis, known to be associated with a decrease in void volume. The observed changes are consistent with urethral obstruction induced by local swelling and inflammation.
  • Fishbein Family Foundation; Interstitial Cystitis Association; Mae Stone Goode Foundation; Departments of Obstetrics and Gynecology, and of Urology; NIH grant: DK 057679.
Language
  • English
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