English, Article edition: Preferences of Patients with Advanced Colorectal Cancer for Treatment with Oral or Intravenous Chemotherapy Candida M. Mastroianni; Caterina Viscomi; Silvia Ceniti; ...

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Physical Description
  • article
Language
  • English

Edition details

Title
  • Preferences of Patients with Advanced Colorectal Cancer for Treatment with Oral or Intravenous Chemotherapy
Author
  • Candida M. Mastroianni
  • Caterina Viscomi
  • Silvia Ceniti
  • Rosanna De Simone
  • Aldo Filice
  • Gennaro Gadaleta Caldarola
  • Stefania Infusino
  • Caterina Manfredi
  • Antonio Rea
  • Claudia Sandomenico
  • Salvatore Turano
  • Francesco Serrano
  • Giovanni Condemi
  • Carla Cortese
  • Tullia Prantera
  • Salvatore Palazzo
Physical Description
  • article
Notes
  • Background: In recent years, patient-reported outcomes such as health-related quality of life have become important areas of clinician focus in general cancer management. Patients' preferences for, and/​or satisfaction with, oral versus intravenous (IV) chemotherapy schedules may have a major impact on such outcomes. Objective: To evaluate preferences for oral or IV chemotherapy in patients with advanced colorectal cancer. Methods: A multicenter, randomized, crossover trial was conducted in 12 hospitals in Southern Italy, in which 22 patients with advanced colorectal cancer received one cycle of oral capecitabine +- irinotecan or oxaliplatin, followed by one cycle of an IV de Gramont or similar regimen (arm A), or the same regimens in reverse order (arm B). Patients were aged 50-70 years and 21% had a higher level of education (graduate or similar). Patients received oral capecitabine 3500 mg/​m2/​day for 7 days (+- irinotecan 180 mg/​m2 or oxaliplatin 85 mg/​m2 on day 1 only), followed by an IV de Gramont regimen +- irinotecan (FOLFIRI) or oxaliplatin (FOLFOX); or the two schedules administered in reverse order. The main outcome measure was patients' preferences for oral versus IV chemotherapy, as determined by a pre- and post-treatment therapy preference questionnaire (TPQ). Results: Before treatment, 75% of patients preferred oral therapy. Characteristics that patients considered to be important were that treatment should not interfere with daily activities (100% of patients) and should not cause fatigue (95%), diarrhea (76%), or painful mouth ulcers (76%); other factors considered important were the risk of infection and nausea (90%), and that treatment could be administered at home (65%). After receiving both chemotherapy schedules, only 45% of patients preferred oral therapy, while 55% preferred IV therapy. Among the latter, the most important characteristics influencing treatment choice were less nausea (66%), fewer mood effects (65%), the safety of hospital IV treatment (62%), less interference with family relationships (55%), less vomiting (55%), less interference with daily activities (50%), and less diarrhea (50%). Although the order in which patients received therapy did not influence treatment preference, significantly fewer patients with a lower rather than higher educational level preferred oral therapy (47% vs 80%; chi-square test =​ 9.9; p_=​_0.002). Conclusion: These results suggest that there may be a correlation between educational level and the preference of patients with advanced colorectal cancer for oral or IV chemotherapy. DOI: 10.2165/​1312067-200801030-00005
  • Adverse-drug-reactions, Antineoplastics, Colorectal-cancer, Intravenous, Oral, Patient-preference
  • RePEc:wkh:thepat:v:1:y:2008:i:3:p:181-187
Language
  • English
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