English, Article edition: Health-Related Quality-of-Life Outcomes in Patients Treated with Push-Pull OROS Hydromorphone versus Extended-Release Oxycodone for Chronic Hip or Knee Osteoarthritis Pain: A Randomized, Open-Label, Parallel-Group, Multicenter Study Kavita Gajria; Mark Kosinski; Jeff Schein; ...

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Bookmark: http://trove.nla.gov.au/version/45987
Physical Description
  • article
Language
  • English

Edition details

Title
  • Health-Related Quality-of-Life Outcomes in Patients Treated with Push-Pull OROS Hydromorphone versus Extended-Release Oxycodone for Chronic Hip or Knee Osteoarthritis Pain: A Randomized, Open-Label, Parallel-Group, Multicenter Study
Author
  • Kavita Gajria
  • Mark Kosinski
  • Jeff Schein
  • Shane Kavanagh
  • Dominique Dubois
Physical Description
  • article
Notes
  • Background: Chronic osteoarthritis (OA) pain impacts health-related quality of life (HR-QOL). Objective: The primary aim of this study was to evaluate and compare HR-QOL outcomes following treatment with once-daily push-pull Osmotic controlled-Release Oral delivery System (OROS) hydromorphone versus twice-daily extended-release (ER) oxycodone for moderate to severe chronic knee or hip OA pain. Methods: This was a 6-week, randomized, open-label, parallel-group, multicenter study of 124 patients with OA whose pre-trial treatment included NSAIDs or other non-steroidal, non-opioid analgesics. The HR-QOL of patients was assessed using the Medical Outcomes Study (MOS) Sleep Scale and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC(TM)). Within- and between-group changes from baseline to 6 weeks were evaluated using ANOVA. Results: At baseline, trial patients had significantly worse MOS Sleep Scale (multivariate ANOVA [MANOVA] F_=​_11.0, p_<_0.001) and WOMAC(TM) scores (MANOVA F_=​_55.7, p_<_0.001) than chronic disease benchmarks. Both treatment groups showed significant improvements on the sleep disturbance scale (p_<_0.01), with additional improvements observed with OROS hydromorphone on the sleep quantity (p_=​_0.046), sleep snoring (p_=​_0.044), awaken short of breath or with a headache (p_=​_0.024), 6-item sleep problems index I (p_<_0.001), and 9-item sleep problems index II (p_<_0.001) scales. Significant treatment differences in favor of OROS hydromorphone over ER oxycodone were also observed on the awaken short of breath or with a headache (p_=​_0.014) scale and sleep problems index I (p_=​_0.045). Both treatment groups showed comparable large effect size (>0.8 SD unit) improvements on the WOMAC(TM) scale (measuring functionality outcomes such as pain, stiffness, physical function etc). Conclusion: Both OROS hydromorphone and ER oxycodone improved sleep and function, with greater sleep benefits being observed in patients treated with OROS hydromorphone. DOI: 10.2165/​1312067-200801030-00009
  • Hydromorphone, Opioid-analgesics, Osteoarthritis, Oxycodone, Quality-of-life, Randomised-controlled-trials
  • RePEc:wkh:thepat:v:1:y:2008:i:3:p:223-238
Language
  • English
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