2003-01-01, English, Article, Journal or magazine article edition: Leukaemia inhibitory factor retards the progression of atherosclerosis Rolfe, Barbara E.; Stamatiou, Steve; World, Cameron J.; ...

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Bookmark: http://trove.nla.gov.au/version/49438935
Physical Description
  • journal article
Published
  • Elsevier Science, 2003-01-01
Language
  • English

Edition details

Title
  • Leukaemia inhibitory factor retards the progression of atherosclerosis
Author
  • Rolfe, Barbara E.
  • Stamatiou, Steve
  • World, Cameron J.
  • Brown, Lindsay
  • Thomas, Anita C.
  • Bingley, John A.
  • Worth, Nathalie F.
  • Campbell, Julie H.
Published
  • Elsevier Science, 2003-01-01
Physical Description
  • journal article
Subjects
Summary
  • Objective: Our previous studies showed that the pleiotropic cytokine leukaemia inhibitory factor (LIF) inhibits the de novo formation of experimental atherosclerotic lesions. The present study examined whether LIF also inhibits progression of pre-existing atheroma. Methods: Balloon angioplasty was performed on the right carotid arteries of 18 rabbits immediately before placing animals on a cholesterol-enriched diet. After 4 weeks, at which time the intima:media ratio (IN) was 0.99+/​-0.12 (n=​6), osmotic minipumps containing LIF (n=​6) or saline control n=​6) were inserted into the peritoneal cavity of each of the remaining rabbits for a further 4 weeks. Arteries were then harvested for analysis. Results: Continuous administration of LIF for the final 4 weeks of an 8-week cholesterol-enriched diet completely inhibited lesion progression in injured carotid arteries (I:M 1.05+/​-0.16) compared with the saline-treated group at 8 weeks (1.62+/​-0.13; P
Language
  • English
Related Resource
Identifier
  • oai:espace.library.uq.edu.au:UQ:67126

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