1996-07-03, English, Article, Journal or magazine article edition: Radiotherapy-related lung fibrosis enhanced by tamoxifen. Bentzen, Soren M.; Skoczylas, Jerzy Z.; Overgaard, Marie; ...

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Physical Description
  • table
  • graph
  • Magazine/​Journal article
Published
  • U.S. National Cancer Institute, 1996 July 3
Language
  • English

Edition details

Title
  • Radiotherapy-related lung fibrosis enhanced by tamoxifen.
Appears In
  • Journal of the National Cancer Institute, v88, no.n13, 1996 July 3, p918(5) (ISSN: 0027-8874)
Author
  • Bentzen, Soren M.
  • Skoczylas, Jerzy Z.
  • Overgaard, Marie
  • Overgaard, Jens
Published
  • U.S. National Cancer Institute, 1996 July 3
Physical Description
  • table
  • graph
  • Magazine/​Journal article
Subjects
Target Audience
  • Professional
Summary
  • Background: Tamoxifen is an anti-estrogen with proven efficacy and low toxicity in the treatment of breast cancer. However, tamoxifen has been shown to exert a number of nonhormonal as well as hormonal effects. One nonhormonal effect of tamoxifen is the induction of transforming growth factor-[beta] (TGF-[beta]) secretion. TGF-[beta] has been implicated in the pathogenesis of radiation-induced fibrosis. Purpose: We investigated the development of lung fibrosis in breast cancer patients who were treated after mastectomy with radiotherapy, with or without simultaneous adjuvant treatment with tamoxifen. Methods: Data from 196 women were included in the analysis. Eighty-four women were postmenopausal patients who participated in a randomized trial testing tamoxifen as an adjuvant to postmastectomy radio-therapy therapy. The radiotherapy technique employed an 8-MV photon field covering the axillary and the infraclavicular and supraclavicular regions of the affected side of the chest; the chest wall was treated with an abutted electron field. Optical density changes in pretreatment and post-treatment chest x-ray films were used to monitor the development of lung fibrosis; lung reactions were assessed in the photon-irradiated field only. Logistic regression analysis was used to explore relationships between radiation dose and the development of lung fibrosis in patients either receiving or not receiving tamoxifen. All P values are from two-sided tests. Results: Among the a women who participated in the randomized trial of radiotherapy plus tamoxifen (n =​ 38) versus radiotherapy alone (n =​ 46), there was a significant association between tamoxifen treatment and the incidence of marked lung fibrosis (relative risk =​ 2.0; 95% confidence interval [CI] =​ 1.2-3.5; P =​ .01). When logistic regression analysis was used to evaluate data from all 196 patients, a highly significant relationship was found between the incidence of lung fibrosis and total radiation dose (P =​ .0005). In the full analysis, an increased risk of marked lung fibrosis was found again for patients who received tamoxifen simultaneously with radiotherapy (with patients receiving radiotherapy alone as the referent, odds ratio =​ 2.9; 95% CI =​ 1.3-6.3; P =​.007). Patient age and menopausal status did not significantly influence the results. Conclusion: Tamoxifen treatment during postmastectomy radiotherapy enhances the risk of radiation-induced lung fibrosis. Implications: In view of pre-existing data, we hypothesize that tamoxifen mediates the enhancement of radiation-induced lung fibrosis through the induction of TGF-[beta] secretion. If this hypothesis is correct, new strategies might be devised for preventing or reducing radiation-induced fibrosis. Because we studied a relatively small portion of the irradiated lung, we cannot recommend changes in current therapeutic measures; however, we strongly encourage additional studies of lung fibrosis in patients receiving tamoxifen and radiotherapy. [J Natl Cancer Inst 1996;88:918-22]
Notes
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Terms of Use
  • COPYRIGHT 1996 U.S. Department of Health and Human Services
Language
  • English
Database
  • Gale Academic OneFile
  • Gale General OneFile
  • Gale Expanded Academic
Identifier
  • 18475159

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Library Access Call number(s) Formats held Language
Austin Health. Austin Health Library. Not open to the public Electronic Resource; v.88-; 1996- Periodical; Journal, magazine, other English
Australian Nuclear Science and Technology Organisation. ANSTO Library. Not open to the public Held. Check with Library Periodical; Journal, magazine, other English
Barwon Health. Barwon Health Library Service. Not open to the public Held. Check Holdings: https://bh.on.worldcat.org Periodical; Journal, magazine, other English
Charles Sturt University. CSU Library - Electronic Resources (shared). Open to the public 000896701; Full Text Available; Highwire Press Free - Available from 1996 volume: 88 issue: 1. Most recent 1 year(s) not available Periodical; Journal, magazine, other English
CSIRO. Black Mountain Library. May not be open to the public 998984270001981; RIVER S Jou; Vol. 13, no. 5 (1953) Periodical; Journal, magazine, other English
Department of Health. Health Library. Not open to the public PER 1739; Print copies 1989-1995 ; Online from 1996 Periodical; Journal, magazine, other English
Edith Cowan University. Edith Cowan University Library. Open to the public Periodical; Journal, magazine, other English
Flinders University. Flinders University Central Library. Open to the public 9956606701771; 616.9905 N27 Periodical; Journal, magazine, other English
Garvan Institute of Medical Research. Curran Foundation Library. May not be open to the public Vol. 83, no. 13 (July 1991)- Periodical; Journal, magazine, other English
James Cook University. Townsville Campus Library. Open to the public Vol. 46 - v. 74, no. 5; 1971 - 1985 Periodical; Journal, magazine, other English
Liverpool Hospital. Ken Merten Library. May not be open to the public V.86 - 98; (1994) - (2006) Periodical; Journal, magazine, other English
Macquarie University. Macquarie University Library. Open to the public 995698710802171; RC261.A1 .U47; Vol. 52 (1974)-vol. 98 (2006) Periodical; Journal, magazine, other English
Monash Health. Not open to the public Held. Check Holdings: https://monash.on.worldcat.org Periodical; Journal, magazine, other English
Monash University. Monash University Library. Open to the public 99516601751; 616.99406 U58J; v. 1 (1940) to v. 100(2008) ; & indexes ; incomplete; Lacks : v. 20 (1958) ; v. 48, no. 1 (1972) ; v. 50, no. 2 (1973) ; v. 55, no. 1 (1975) ; v. 91, no. 13-24 (1999) v. 94, no. 12, 13, 15 to 17, 23 (2002); OS; YOS-SER Periodical; Journal, magazine, other English
Murdoch University. Murdoch University Library. Open to the public 950186B; 616.994/N277/1<950186B> Vol. 59 (1977)-; Vol. 59 (1977)-v. 90 (1998) Periodical; Journal, magazine, other English
National Library of Australia. Open to the public S 616.994 UNI; Vol. 1, no. 1-; Aug. 1940- Periodical; Journal, magazine, other English
Prince Charles Hospital. The Prince Charles Hospital Library. Not open to the public v.88-; 1996- Periodical; Journal, magazine, other English
Royal Melbourne Hospital. Royal Melbourne Hospital Health Sciences Library incorporating the Victorian Mental Health Library. May not be open to the public V. 1 (1940) - Present; PDF OK Periodical; Journal, magazine, other English
Southern Cross University. University Library Lismore. Open to the public Electronic resource - Check catalogue for holdings Periodical; Journal, magazine, other English
South Metropolitan Health Service Library. Royal Perth Hospital (South and East Metropolitan Health Service). Open to the public Vol. 67-v. 86 no. 17; 1981-1994, v.80, 1988+ Periodical; Journal, magazine, other English
State Library of NSW. Open to the public State Reference Library held; Vol. 1 (1940/41)-Nov. 1982 Periodical; Journal, magazine, other English
State Library of Western Australia. Open to the public .b15182368; held Periodical; Journal, magazine, other English
State Library Victoria. Open to the public held; Vol. 10, no. 1-v. 69, no. 6; Aug. 1949-Dec. 1982 Periodical; Journal, magazine, other English
St Vincent's Hospital (Melbourne). Carl de Gruchy Library. May not be open to the public NAT; v.80-87; 1988-1995 Periodical; Journal, magazine, other English
St Vincent's Hospital (Sydney). Walter McGrath Library. Not open to the public 80(1988) -101(2009); Online Access 1996 - Can only supply Libraries in Australia & Non for profit libraries Periodical; Journal, magazine, other English
The Royal Children's Hospital. J.W. Grieve Memorial Library. Not open to the public v.88-; 1996-; **DocDel PDF ok to Australian non-commercial only. Periodical; Journal, magazine, other English
The Townsville Hospital. Townsville Health Library. Not open to the public v.87, no. 10(1995) - v.101(2009), 991974402062; v.87, no. 10(1995) - v.101(2009) Periodical; Journal, magazine, other English
The University of Melbourne. The University of Melbourne Library. Open to the public BioMed P JOUR; v.1-v.96; 1940/41-2004; incomplete Periodical; Journal, magazine, other English
The University of Sydney. University of Sydney Library. Open to the public held; Vol. 81, no. 1 (989)- md; Vol. 1, no. 1 (Aug. 1940)-v. 79, no. 6 (Dec. 1987); Imperfect Periodical; Journal, magazine, other English
Trinity Theological College (Perth, WA). Trinity Theological College Library. Open to the public Held. Not for ILL. Periodical; Journal, magazine, other English
University of Newcastle. University of Newcastle Library. Open to the public S616.994005/10/MM; Vol. 68, no. 3-v. 88, no. 3-4; Mar. 1982-21 Feb. 1996 Periodical; Journal, magazine, other English
University of Western Australia. University of Western Australia Library. Open to the public 9945466102101; HELD; V. 1-59 ; 1940-1977; V. 60-63, 64(1, 4-6), 65, 66(1, 3-6), 67-69, 70(1-2, 4-6), 71-75, 76(1-5), 77(2-6), 78-98 ; 1978-2006 Periodical; Journal, magazine, other English
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These 3 locations in Australian Capital Territory:

Library Access Call number(s) Formats held Language
CSIRO. Black Mountain Library. May not be open to the public 998984270001981; RIVER S Jou; Vol. 13, no. 5 (1953) Periodical; Journal, magazine, other English
Department of Health. Health Library. Not open to the public PER 1739; Print copies 1989-1995 ; Online from 1996 Periodical; Journal, magazine, other English
National Library of Australia. Open to the public S 616.994 UNI; Vol. 1, no. 1-; Aug. 1940- Periodical; Journal, magazine, other English
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These 10 locations in New South Wales:

Library Access Call number(s) Formats held Language
Australian Nuclear Science and Technology Organisation. ANSTO Library. Not open to the public Held. Check with Library Periodical; Journal, magazine, other English
Charles Sturt University. CSU Library - Electronic Resources (shared). Open to the public 000896701; Full Text Available; Highwire Press Free - Available from 1996 volume: 88 issue: 1. Most recent 1 year(s) not available Periodical; Journal, magazine, other English
Garvan Institute of Medical Research. Curran Foundation Library. May not be open to the public Vol. 83, no. 13 (July 1991)- Periodical; Journal, magazine, other English
Liverpool Hospital. Ken Merten Library. May not be open to the public V.86 - 98; (1994) - (2006) Periodical; Journal, magazine, other English
Macquarie University. Macquarie University Library. Open to the public 995698710802171; RC261.A1 .U47; Vol. 52 (1974)-vol. 98 (2006) Periodical; Journal, magazine, other English
Southern Cross University. University Library Lismore. Open to the public Electronic resource - Check catalogue for holdings Periodical; Journal, magazine, other English
State Library of NSW. Open to the public State Reference Library held; Vol. 1 (1940/41)-Nov. 1982 Periodical; Journal, magazine, other English
St Vincent's Hospital (Sydney). Walter McGrath Library. Not open to the public 80(1988) -101(2009); Online Access 1996 - Can only supply Libraries in Australia & Non for profit libraries Periodical; Journal, magazine, other English
The University of Sydney. University of Sydney Library. Open to the public held; Vol. 81, no. 1 (989)- md; Vol. 1, no. 1 (Aug. 1940)-v. 79, no. 6 (Dec. 1987); Imperfect Periodical; Journal, magazine, other English
University of Newcastle. University of Newcastle Library. Open to the public S616.994005/10/MM; Vol. 68, no. 3-v. 88, no. 3-4; Mar. 1982-21 Feb. 1996 Periodical; Journal, magazine, other English
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None of your libraries hold this item.

These 3 locations in Queensland:

Library Access Call number(s) Formats held Language
James Cook University. Townsville Campus Library. Open to the public Vol. 46 - v. 74, no. 5; 1971 - 1985 Periodical; Journal, magazine, other English
Prince Charles Hospital. The Prince Charles Hospital Library. Not open to the public v.88-; 1996- Periodical; Journal, magazine, other English
The Townsville Hospital. Townsville Health Library. Not open to the public v.87, no. 10(1995) - v.101(2009), 991974402062; v.87, no. 10(1995) - v.101(2009) Periodical; Journal, magazine, other English
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This single location in South Australia:

Library Access Call number(s) Formats held Language
Flinders University. Flinders University Central Library. Open to the public 9956606701771; 616.9905 N27 Periodical; Journal, magazine, other English
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None of your libraries hold this item.

These 9 locations in Victoria:

Library Access Call number(s) Formats held Language
Austin Health. Austin Health Library. Not open to the public Electronic Resource; v.88-; 1996- Periodical; Journal, magazine, other English
Barwon Health. Barwon Health Library Service. Not open to the public Held. Check Holdings: https://bh.on.worldcat.org Periodical; Journal, magazine, other English
Monash Health. Not open to the public Held. Check Holdings: https://monash.on.worldcat.org Periodical; Journal, magazine, other English
Monash University. Monash University Library. Open to the public 99516601751; 616.99406 U58J; v. 1 (1940) to v. 100(2008) ; & indexes ; incomplete; Lacks : v. 20 (1958) ; v. 48, no. 1 (1972) ; v. 50, no. 2 (1973) ; v. 55, no. 1 (1975) ; v. 91, no. 13-24 (1999) v. 94, no. 12, 13, 15 to 17, 23 (2002); OS; YOS-SER Periodical; Journal, magazine, other English
Royal Melbourne Hospital. Royal Melbourne Hospital Health Sciences Library incorporating the Victorian Mental Health Library. May not be open to the public V. 1 (1940) - Present; PDF OK Periodical; Journal, magazine, other English
State Library Victoria. Open to the public held; Vol. 10, no. 1-v. 69, no. 6; Aug. 1949-Dec. 1982 Periodical; Journal, magazine, other English
St Vincent's Hospital (Melbourne). Carl de Gruchy Library. May not be open to the public NAT; v.80-87; 1988-1995 Periodical; Journal, magazine, other English
The Royal Children's Hospital. J.W. Grieve Memorial Library. Not open to the public v.88-; 1996-; **DocDel PDF ok to Australian non-commercial only. Periodical; Journal, magazine, other English
The University of Melbourne. The University of Melbourne Library. Open to the public BioMed P JOUR; v.1-v.96; 1940/41-2004; incomplete Periodical; Journal, magazine, other English
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None of your libraries hold this item.

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