2009-01-05, English, Article, Journal or magazine article edition: Breaking the VE-cadherin bonds. Gavard, Julie

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Physical Description
  • Magazine/​Journal article
Published
  • Elsevier B.V., 2009 Jan 5
Language
  • English

Edition details

Title
  • Breaking the VE-cadherin bonds.
Appears In
  • FEBS Letters, v.583, no.1, 2009 Jan 5, p.1(6) (ISSN: 0014-5793)
Author
  • Gavard, Julie
Published
  • Elsevier B.V., 2009 Jan 5
Physical Description
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • To link to full-text access for this article, visit this link: http:/​/​dx.doi.org/​10.1016/​j.febslet.2008.11.032 Byline: Julie Gavard Keywords: Vascular permeability; Angiogenesis; VEGF; Adhesion; Cytoskeleton; Tight junctions Abstract: Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture. Conversely, anti-PIFs protect from VE-cadherin disruption and enhance cell cohesion. These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis. Author Affiliation: Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Paris, France Inserm, U567, Paris, France Article History: Received 24 October 2008; Accepted 18 November 2008
Terms of Use
  • COPYRIGHT 2009 Elsevier B.V.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 202133235

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