2006-04-07, English, Article, Journal or magazine article edition: Unraveling ICAP-1 function: Toward a new direction? Bouvard, Daniel; Millon-Fremillon, AngeLique; Dupe-Manet, Sandra; ...

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Physical Description
  • Magazine/​Journal article
Published
  • Elsevier B.V., 2006 April 7
Language
  • English

Edition details

Title
  • Unraveling ICAP-1 function: Toward a new direction?
Appears In
  • European Journal of Cell Biology, v.85, no.3-4, 2006 April 7, p.275(8) (ISSN: 0171-9335)
Author
  • Bouvard, Daniel
  • Millon-Fremillon, AngeLique
  • Dupe-Manet, Sandra
  • Block, Marc R.
  • Albiges-Rizo, Corinne
Published
  • Elsevier B.V., 2006 April 7
Physical Description
  • Magazine/​Journal article
Subjects
Target Audience
  • Academic
Summary
  • To link to full-text access for this article, visit this link: http:/​/​dx.doi.org/​10.1016/​j.ejcb.2005.10.005 Byline: Daniel Bouvard, Angelique Millon-Fremillon, Sandra Dupe-Manet, Marc R. Block, Corinne Albiges-Rizo Keywords: ICAP-1; Integrin signaling; Krit-1; Nm23-H2 Abstract: Cell adhesion to either the extracellular matrix (ECM) or to neighboring cells is of critical importance during both physiological and pathological situations. Integrins are a large family of cell adhesion receptors composed of two non-covalently linked [alpha] and [beta] subunits. They have a well-identified dual function of mediating both firm adhesion and signaling. The short cytoplasmic domain of integrin can interact with cytoplasmic proteins that are either shared by several different integrins or specific for one type of integrin. Integrin cytoplasmic domain-associated protein-1 (ICAP-1) is a small cytoplasmic protein that specifically interacts with the [beta].sub.1 integrin subunit. In this review we will discuss recent findings on ICAP-1, not only at the structural and functional level, but also its possible interconnection in other signaling pathways such as those that control cell proliferation. Author Affiliation: LEDAC, UMR CNRS/UJF 5538, Institut Albert Bonniot, Domaine de la Merci, Faculte de Medecine, F-38706 La Tronche Cedex, France
Terms of Use
  • COPYRIGHT 2006 Elsevier B.V.
Language
  • English
Database
  • Gale Academic OneFile
Identifier
  • 198013144

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