2004, English, Article edition: Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type Behnke, B.J; Delp, M.D; McDonough, P; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/210819
Physical Description
  • text/​html
Published
  • Oxford University Press
  • 2004-02-01 00:00:00.0
Language
  • English

Edition details

Title
  • Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type
Author
  • Behnke, B.J
  • Delp, M.D
  • McDonough, P
  • Spier, S.A
  • Poole, D.C
  • Musch, T.I
Published
  • Oxford University Press
  • 2004-02-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • In rat spinotrapezius muscle, chronic heart failure (CHF) speeds microvascular O 2 pressure ( p O 2 ; index of O 2 delivery-to-O 2 uptake) dynamics across the rest–contractions transition [Cardiovasc. Res. 56 (2002) 479]. Due to the mosaic nature of this muscle, the effect of CHF on microvascular p O 2 dynamics in different fiber types remains unclear. Objective: Based upon derangements of endothelial function and blood flow responses, we hypothesized that CHF would speed microvascular p O 2 dynamics (reduced O 2 delivery-to-O 2 uptake ratio) in type I muscle (soleus, <IMG SRC=​"/​math/​sim.gif" ALT=​"~" BORDER=​"0">84% type I), but not in type II muscle (peroneal, <IMG SRC=​"/​math/​sim.gif" ALT=​"~" BORDER=​"0">86% type II [J. Appl. Physiol. 80 (1996) 261]). Methods: Using phosphorescence quenching, microvascular p O 2 was measured at rest and across the rest–contractions transition (1 Hz) in soleus and peroneal of non-infarcted control (control; n =​ 7), and Sprague–Dawley rats with moderate (moderate; elevated left ventricular end-diastolic pressure (LVEDP) 10±2 mm Hg; n =​ 10) and severe (severe; LVEDP 28±4 mm Hg; n =​ 5) CHF. Results: The microvascular p O 2 mean response time (time delay+time constant) was progressively speeded with increasing severity of CHF in soleus (control, 38.7±2.0; moderate, 29.1±1.5; severe, 22.5±3.9 s; P <IMG SRC=​"/​math/​le.gif" ALT=​"≤" BORDER=​"0">0.05), but not in peroneal (control=​moderate=​severe). Conclusion: As type I fibers are recruited predominately for moderate intensity exercise, the more rapid lowering of soleus microvascular p O 2 in CHF would reduce the blood-muscle O 2 driving gradient, exacerbate phosphocreatine and glycogen breakdown, and provide a mechanism for slowed O 2 uptake kinetics and premature fatigue in CHF.
Terms of Use
  • Copyright (C) 2004, European Society of Cardiology
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment