1993, English, Article edition: The fuzzy-end elimination theorem: correctly implementing the side chain placement algorithm based on the dead-end elimination theorem Lasters, Ignace; Desmet, Johan

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/210494
Physical Description
  • text/​html
Published
  • Oxford University Press
  • 1993-09-01 00:00:00.0
Language
  • English

Edition details

Title
  • The fuzzy-end elimination theorem: correctly implementing the side chain placement algorithm based on the dead-end elimination theorem
Author
  • Lasters, Ignace
  • Desmet, Johan
Published
  • Oxford University Press
  • 1993-09-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • Recently it has been shown that the dead-end elimination theorem is a powerful tool in the search for the global minimum energy conformation (GMEC) of a large collection of protein side chains given known backbone coordinates and a library of allowed side chain conformational states, also known as rotamers. A side chain placement algorithm based on this theorem iteratively applies this theorem to single as well as to pairs of rotamers leading to the identification of rotamers, single or pairs, that are incompatible with the GMEC and that can thus be qualified as ‘dead-ending’. Here we formulate a theorem which proves that contrary to intuition dead-end rotamer pairs can not simply be discarded from consideration in the iterative process leading to the further elimination of dead-end rotamers. We refer to this theorem as the fuzzy-end elimination theorem. We also describe how the obtained dead-end rotamer pairs can contribute to the search for the GMEC in the protein side chain placement problem. Hence the present work forms a theoretical basis for the correct implementation of a side chain placement algorithm based on the dead-end elimination theorem. In addition, possible future perspectives are presented.
Terms of Use
  • Copyright (C) 1993, Oxford University Press
Language
  • English
Contributed by
OAIster

Get this edition

With access conditions

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment