In seventy−seven fit patients, premedicated only with atropine, a linear relationship was found between the dosage of G.29.505 (range 100–800 mg; 1.8–18.1 mg/kg) and sleeping time. This differs from the expected response to similar doses of thiopentone. The difference in recovery from the two drugs may be attributable to variations in their redistribution (and possibly detoxication) in the body. It is postulated that the lack of depressant effects of G.29.505 on the cardiovascular system, and release of adrenaline after injection, may contribute to the rapid recovery, even after large doses, from the effects of this drug.
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