2008, English, Article edition: Early impairment of left ventricular long-axis systolic function demonstrated by reduced atrioventricular plane displacement in patients with Marfan syndrome Kiotsekoglou, Anatoli; Bajpai, Abhay; Bijnens, Bart H.; ...

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Physical Description
  • text/​html
Published
  • Oxford University Press
  • 2008-09-01 00:00:00.0
Language
  • English

Edition details

Title
  • Early impairment of left ventricular long-axis systolic function demonstrated by reduced atrioventricular plane displacement in patients with Marfan syndrome
Author
  • Kiotsekoglou, Anatoli
  • Bajpai, Abhay
  • Bijnens, Bart H.
  • Kapetanakis, Venedictos
  • Athanassopoulos, George
  • Moggridge, James C.
  • Mullen, Mike J.
  • Nassiri, Dariush K.
  • Camm, John
  • Sutherland, George R.
  • Child, Anne H.
Published
  • Oxford University Press
  • 2008-09-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • Aims Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 (FBN1) gene. It has been observed that FBN1 deficient mice have reduced left ventricular (LV) systolic function which is correlated to increased transforming growth factor-β activity. This study aimed to ascertain LV functional abnormalities in MFS patients using M-mode and tissue Doppler imaging (TDI). Methods and results In 66 (15–58 years) MFS patients and 61 normal controls, ejection fraction (EF) was evaluated by Simpson's biplane method. Atrioventricular plane displacement (AVPD) obtained from five mitral annular regions was also assessed using M-mode and TDI techniques. To overcome limitations associated with conventional M-mode echocardiography, anatomical and colour anatomical M-mode were also utilized. Ejection fraction was significantly reduced in MFS patients when compared to controls (66.3 ± 0.74 vs. 71.9 ± 0.56, P < 0.001), although it was within the normal range. M-mode and TDI AVPD measurements obtained from lateral, septal, inferior, anterior and posterior mitral annular regions were also significantly reduced in MFS patients in comparison to controls ( P <0.001, for all measurements). Conclusion Left ventricular long-axis systolic function is significantly reduced in MFS patients. This data suggests that LV function should be monitored in MFS and appropriate treatment applied if necessary.
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  • Copyright (C) 2008, European Society of Cardiology
Language
  • English
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