2009, English, Article edition: Statistical effects of dose deposition in track-structure modeling of radiobiology efficiency Beuve, Michael; Colliaux, A.; Dabli, D.; ...

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Physical Description
  • text
Published
  • HAL - CCSD
  • 2009
Language
  • English

Edition details

Title
  • Statistical effects of dose deposition in track-structure modeling of radiobiology efficiency
Author
  • Beuve, Michael
  • Colliaux, A.
  • Dabli, D.
  • Dauvergne, D.
  • Gervais, B.
  • Montarou, G.
  • Testa, E.
Published
  • HAL - CCSD
  • 2009
Physical Description
  • text
Subjects
Notes
  • Ion-induced cell killing has been reported to depend on irradiation dose but also projectile parameters. In this paper we focus on two approaches developed and extensively used to predict cell survival in response to ion irradiation: the Local Effect Model and the Katz Model. These models are based on a track-structure description summarized in the concept of radial dose. This latter is sensitive to ion parameters and gives to both models the ability to predict some important radiobiological features for ion irradiations. Radial dose is however an average quantity, which does not include stochastic effects. These radiation-intrinsic effects are investigated by means of a Monte-Carlo simulation of dose deposition. We show that both models are not fully consistent with the nanometric and microscopic dose deposition statistics.
  • HAL:hal-00275539, version 1
  • HAL:http:/​/​hal.archives-ouvertes.fr/​hal-00275539/​en/​
  • DOI:10.1016/​j.nimb.2009.02.016
Language
  • English
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