1998, English, Article edition: Is the measurement of placental protein-14 and CA-125 in plasma and uterine flushings useful in the evaluation of peri-menopausal and post-menopausal bleeding? Li, T.C.; Okon, M.A.; Dalton, C.F.; ...

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Physical Description
  • text/​html
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Language
  • English

Edition details

Title
  • Is the measurement of placental protein-14 and CA-125 in plasma and uterine flushings useful in the evaluation of peri-menopausal and post-menopausal bleeding?
Author
  • Li, T.C.
  • Okon, M.A.
  • Dalton, C.F.
  • Heatley, M.
  • Laird, S.M.
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • In this prospective study, we examined the possible diagnostic value of the measurement of two endometrial proteins, placental protein-14 (PP14) and CA-125, in the evaluation of pre- and post-menopausal bleeding. Concentrations of these two proteins were measured in plasma and uterine flushings obtained from 139 pre- and post-menopausal women with bleeding problems, and 26 normal post-menopausal control women without bleeding. Endometrial biopsy samples were also obtained for histological study. Concentrations of PP14 in both the plasma and uterine flushings in post-menopausal women were significantly lower ( P < 0.001) than those of control pre-menopausal women. In post-menopausal women, the concentrations of PP14 (mean ± SEM) in both plasma and flushing were significantly higher ( P < 0.001) in women with endometrial adenocarcinoma (46.9 ± 7.5 ng/​ml plasma; 3350 ± 1711 ng/​ml flushing) than in the controls (7.6 ± 1.3 ng/​ml plasma; 125 ± 27 ng/​ml flushing) or in women with post-menopausal bleeding and atrophic endometrium (20.4 ± 2.1 ng/​ml plasma; 453 ± 167 ng/​ml flushing). In contrast CA-125 concentrations in plasma and flushings were similar in post-menopausal and pre-menopausal women. Plasma concentrations of CA-125 were higher in post-menopausal women with adenocarcinoma (29.1 ± 7.4 IU/​ml) than in those with post-menopausal bleeding and atrophic endometrium (21.8 ± 2 IU/​ml) ( P < 0.05) or control post-menopausal subjects (16.1 ± 2.1 IU/​ml) ( P < 0.01). CA-125 concentrations in uterine flushings were not significantly different in any group of post-menopausal women. The results show that concentrations of PP14 are correlated more strongly to endometrial histopathology than those of CA-125 in pre- and post-menopausal women. Elevated PP14 concentrations are also associated with the presence of endometrial adenocarcinoma and may have a potential to be used as a marker for this disease.
Terms of Use
  • Copyright (C) 1998, European Society of Human Reproduction and Embryology
Language
  • English
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