1998, English, Article
Is the measurement of placental protein-14 and CA-125 in plasma and uterine flushings useful in the evaluation of peri-menopausal and post-menopausal bleeding?
Li, T.C.; Okon, M.A.; Dalton, C.F.; ...
In this prospective study, we examined the possible diagnostic value of the measurement of two endometrial proteins, placental protein-14 (PP14) and CA-125, in the evaluation of pre- and post-menopausal bleeding. Concentrations of these two proteins were measured in plasma and uterine flushings obtained from 139 pre- and post-menopausal women with bleeding problems, and 26 normal post-menopausal control women without bleeding. Endometrial biopsy samples were also obtained for histological study. Concentrations of PP14 in both the plasma and uterine flushings in post-menopausal women were significantly lower ( P < 0.001) than those of control pre-menopausal women. In post-menopausal women, the concentrations of PP14 (mean ± SEM) in both plasma and flushing were significantly higher ( P < 0.001) in women with endometrial adenocarcinoma (46.9 ± 7.5 ng/ml plasma; 3350 ± 1711 ng/ml flushing) than in the controls (7.6 ± 1.3 ng/ml plasma; 125 ± 27 ng/ml flushing) or in women with post-menopausal bleeding and atrophic endometrium (20.4 ± 2.1 ng/ml plasma; 453 ± 167 ng/ml flushing). In contrast CA-125 concentrations in plasma and flushings were similar in post-menopausal and pre-menopausal women. Plasma concentrations of CA-125 were higher in post-menopausal women with adenocarcinoma (29.1 ± 7.4 IU/ml) than in those with post-menopausal bleeding and atrophic endometrium (21.8 ± 2 IU/ml) ( P < 0.05) or control post-menopausal subjects (16.1 ± 2.1 IU/ml) ( P < 0.01). CA-125 concentrations in uterine flushings were not significantly different in any group of post-menopausal women. The results show that concentrations of PP14 are correlated more strongly to endometrial histopathology than those of CA-125 in pre- and post-menopausal women. Elevated PP14 concentrations are also associated with the presence of endometrial adenocarcinoma and may have a potential to be used as a marker for this disease.
Copyright (C) 1998, European Society of Human Reproduction and Embryology
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