1998, English, Article edition: Immunoneutralization of follicle stimulating hormone does not affect gonadotrophin surge-inhibiting factor/ attenuating factor bioactivity during the rat ovarian cycle Tio, S.; van Dieten, J.A.M.J.; de Koning, J.

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/205555
Physical Description
  • text/​html
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Language
  • English

Edition details

Title
  • Immunoneutralization of follicle stimulating hormone does not affect gonadotrophin surge-inhibiting factor/​ attenuating factor bioactivity during the rat ovarian cycle
Author
  • Tio, S.
  • van Dieten, J.A.M.J.
  • de Koning, J.
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • The physiological role of follicle stimulating hormone (FSH) in the regulation of the release of the putative ovarian factor gonadotrophin surge-inhibiting or -attenuating factor (GnSIF/​AF) was investigated. Blood FSH concentrations were immunoneutralized in female rats during different days of the ovarian cycle. FSH antiserum was injected in different protocols to neutralize the FSH surge(s) and/​or basal FSH concentrations. All animals were killed on the morning of the day of pro-oestrus of the control rats. Hemi-pituitaries were incubated and gonadotrophin-releasing hormone (GnRH) stimulated and basal luteinizing hormone (LH) and FSH releases and pituitary contents were measured. The biological effectiveness of the FSH antiserum was established by monitoring the histology of vaginal smears and inhibin concentrations in trunk-blood. The predominance of small leukocytes in the smears (low oestradiol bioactivity) and the decreased (bioactive) inhibin secretion imply that anti-FSH neutralizes FSH bioactivity. Simultaneously, the results showed that all anti-FSH injections did not affect the biphasic LH response to GnRH in-vitro , which shows an unaltered presence of GnSIF/​AF bioactivity in the blood circulation. The results suggest that under physiological conditions GnSIF/​AF bioactivity, which keeps the LH responsiveness of the pituitary gland suppressed to the action of GnRH, is not supported by inhibin and not controlled by FSH.
Terms of Use
  • Copyright (C) 1998, European Society of Human Reproduction and Embryology
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment