1998, English, Article edition: Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome Dahlgren, E.; Landin, K.; Krotkiewski, M.; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/205531
Physical Description
  • text/​html
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Language
  • English

Edition details

Title
  • Effects of two antiandrogen treatments on hirsutism and insulin sensitivity in women with polycystic ovary syndrome
Author
  • Dahlgren, E.
  • Landin, K.
  • Krotkiewski, M.
  • Holm, G.
  • Janson, P.O.
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • Thirty-two women with polycystic ovary syndrome (PCOS) were allocated to two antiandrogen treatment regimens; 28 women completed the trial. Twenty women were treated with ethinyloestradiol and cyproterone acetate (EO-CA) cyclically for 6 months and eight women were treated with the gonadotrophin releasing hormone (GnRH) analogue, goserelin for 6 months. Effects on hirsutism, insulin sensitivity (estimated by glucose clamp technique), blood lipids and hormones were measured. Women treated with EO-CA showed a reduction in hirsutism ( P <0.05), and decreased serum androgen concentrations ( P <0.001) as well as reduced insulin sensitivity ( P <0.05). In women treated with goserelin, serum androgen concentrations also decreased ( P <0.001), but there was no significant reduction of hirsutism. This group, however, showed an improved insulin sensitivity ( P <0.05) despite an unchanged body mass index. Bone mineral density was unaltered in both treatment groups. The reduction in androgen concentrations caused by EO-CA was not paralleled by increased insulin sensitivity, most probably due to the effect of ethinyloestradiol per se . In contrast, the reduction in androgen concentrations by goserelin was accompanied by an improved insulin sensitivity.
Terms of Use
  • Copyright (C) 1998, European Society of Human Reproduction and Embryology
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment