1998, English, Article edition: Genetic variant of luteinizing hormone in women with a history of recurrent miscarriage Tulppala, Maija; Huhtaniemi, Ilpo; Ylikorkala, Olavi

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Physical Description
  • text/​html
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Language
  • English

Edition details

Title
  • Genetic variant of luteinizing hormone in women with a history of recurrent miscarriage
Author
  • Tulppala, Maija
  • Huhtaniemi, Ilpo
  • Ylikorkala, Olavi
Published
  • Oxford University Press
  • 1998-10-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • Because the biological and clinical significance of a genetic variant of luteinizing hormone (LH) is unclear, we therefore evaluated the occurrence of variant LH in women with a history of recurrent spontaneous abortion (RSA) and related it to specific LH concentrations, luteal function and pregnancy outcome. Of the 85 RSA women, 30 (35.3%) had variant LH (28 heterozygous and two homozygous), and 55 women (64.7%) a normal wild-type LH ratio. These frequencies are similar to those reported from the general Finnish population. No significant differences were observed in specific LH concentrations based on LH status (7.2 ± 1.4 IU/​l, mean ± SEM, variant LH, versus 8.5 ± 1.6 IU/​l, wild-type LH). Variant LH was twice as common in women with body mass index (BMI) > 25 kg/​m2 (9/​15, 60.0%) than in those with BMI ≤25 kg/​m2 (21/​70, 30.0%, P < 0.05). The presence of variant LH was not associated with any clear effect on endocrine variables such as endometrial maturation or mid-luteal phase oestradiol and progesterone concentrations. During follow-up, 23 women with variant LH (76.7%) and 41 with wild-type LH (74.5%) became pregnant: 14 miscarried (21.9%, six with variant LH and eight with wild-type LH) and two had ectopic pregnancies, whereas 48 (75.0%) succeeded (17 with variant LH and 31 with wild-type LH). LH concentrations before pregnancy were similar in women with a successful outcome (8.0 ± 1.3 IU/​l) or with a miscarriage also in that pregnancy (7.4 ± 1.4 IU/​l). In conclusion, variant LH is common in RSA women who are relatively overweight (BMI > 25 kg/​m2) but its presence is not reflected in endometrial maturation and miscarriage rates.
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  • Copyright (C) 1998, European Society of Human Reproduction and Embryology
Language
  • English
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