2009, English, Article edition: When a collective outcome triggers a rare individual event: a mode of metastatic process in a cell population Malo, Michel; Cartier-Michaud, Amandine; Fabre-Guillevin, Elizabeth; ...

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Bookmark: http://trove.nla.gov.au/version/204810
Physical Description
  • text
Published
  • HAL - CCSD
  • 2009
Language
  • English

Edition details

Title
  • When a collective outcome triggers a rare individual event: a mode of metastatic process in a cell population
Author
  • Malo, Michel
  • Cartier-Michaud, Amandine
  • Fabre-Guillevin, Elizabeth
  • Hutzler, Guillaume
  • Delaplace, Franck
  • Barlovatz-Meimon, Georgia
  • Lesne, Annick
Published
  • HAL - CCSD
  • 2009
Physical Description
  • text
Subjects
Notes
  • A model of early metastatic process is based on the role of the protein PAI-1, which at high enough extracellular concentration promotes the transition of cancer cells to a state prone to migration. This transition is described at the single cell level as a bi-stable switch associated with a subcritical bifurcation. In a multilevel reaction-diffusion scenario, the microenvironment of the tumor is modified by the proliferating cell population so as to push the concentration of PAI-1 above the bifurcation threshold. The formulation in terms of partial differential equations fails to capture spatio-temporal heterogeneity. Cellular-automata and agent-based simulations of cell populations support the hypothesis that a randomly localized accumulation of PAI-1 can arise and trigger the escape of a few isolated cells. Far away from the primary tumor, these cells experience a reverse transition back to a proliferative state and could generate a secondary tumor. The proposed role of PAI-1 in controlling this metastatic cycle is candidate to explain its role in the progression of cancer.
  • HAL:hal-00407546, version 2
  • HAL:http:/​/​hal.archives-ouvertes.fr/​hal-00407546/​en/​
Language
  • English
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