Aims This study was designed to investigate the role of inflammation on the occurrence of angiographic restenosis 6 months after coronary stent implantation and the influence of different kinds of antithrombotic and antiplatelet strategies on inflammation. Methods and Results In an open randomized trial, 40 consecutive patients were treated with aspirin (100mg.day−1) and either ticlopidine (2×250mg.day−1) (n=17), or phenprocoumon (INR 2·0–3·0) and dipyridamole (3×160mg.day−1) (n=23) after successful elective coronary stent implantation. Plasma levels of C-reactive protein were determined one day before stent implantation and serially thereafter twice daily up to 120h. C-reactive protein plasma levels increased significantly ( P <0·0001) after stent implantation. Phenprocoumon and dipyridamole or ticlopidine had no effect on C-reactive protein plasma levels ( P =0·51) or the occurrence of angiographic restenosis ( P =0·48). C-reactive protein plasma levels were significantly higher in patients with lesion type C compared to types A or B ( P =0·035), respectively. C-reactive protein plasma levels were significantly higher and mean shoulder levels occurred 48h later in patients with restenosis compared to patients without restenosis after 6 months ( P =0·038). Conclusions Elevated C-reactive protein plasma levels still persisting 96h after stent implantation might reflect a prolonged inflammatory reaction to coronary stent implantation which might causally be involved in pathophysiological mechanisms leading to restenosis.
Copyright (C) 2000, European Society of Cardiology
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