2009, English, Article edition: RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Wang, Xiaobo; Belguise, Karine; O'neill, Christine F.; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/201035
Physical Description
  • text
Published
  • HAL - CCSD
  • 2009
Language
  • English

Edition details

Title
  • RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.
Author
  • Wang, Xiaobo
  • Belguise, Karine
  • O'neill, Christine F.
  • Sánchez-Morgan, Nuria
  • Romagnoli, Mathilde
  • Eddy, Sean
  • Mineva, Nora
  • Yu, Ziyang
  • Min, Chengyin
  • Trinkaus- Randall, Vickery
  • Chalbos, Dany
  • Sonenshein, Gail
Published
  • HAL - CCSD
  • 2009
Physical Description
  • text
Subjects
Notes
  • Aberrant constitutive expression of NF-kappaB subunits, reported in more than 90% of breast cancers and multiple other malignancies, plays pivotal roles in tumorigenesis. Higher RelB subunit expression was demonstrated in estrogen receptor alpha (ERalpha)-negative breast cancers versus ERalpha-positive ones, due in part to repression of RelB synthesis by ERalpha signaling. Notably, RelB promoted a more invasive phenotype in ERalpha-negative cancers via induction of the BCL2 gene. We report here that RelB reciprocally inhibits ERalpha synthesis in breast cancer cells, which contributes to a more migratory phenotype. Specifically, RelB is shown for the first time to induce expression of the zinc finger repressor protein Blimp1 (B-lymphocyte-induced maturation protein), the critical mediator of B- and T-cell development, which is transcribed from the PRDM1 gene. Blimp1 protein repressed ERalpha (ESR1) gene transcription. Commensurately higher Blimp1/​PRDM1 expression was detected in ERalpha-negative breast cancer cells and primary breast tumors. Induction of PRDM1 gene expression was mediated by interaction of Bcl-2, localized in the mitochondria, with Ras. Thus, the induction of Blimp1 represents a novel mechanism whereby the RelB NF-kappaB subunit mediates repression, specifically of ERalpha, thereby promoting a more migratory phenotype.
  • HAL:inserm-00396241, version 1
  • HAL:http:/​/​www.hal.inserm.fr/​inserm-00396241/​en/​
  • PUBMED:19433448
  • DOI:10.1128/​MCB.00032-09
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (2)
  • Unknown (2)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment