2009, English, Article edition: Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study. Salmon, Dominique; Rosenthal, Eric; Lewden, Charlotte; ...

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Physical Description
  • text
Published
  • HAL - CCSD
  • 2009
Language
  • English

Edition details

Title
  • Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study.
Author
  • Salmon, Dominique
  • Rosenthal, Eric
  • Lewden, Charlotte
  • Bouteloup, Vincent
  • May, Thierry
  • Burty, Christine
  • Bonnet, Fabrice
  • Costagliola, Dominique
  • Jougla, Eric
  • Semaille, Caroline
  • Morlat, Philippe
  • Cacoub, Patrice
  • Chêne, Geneviève
Published
  • HAL - CCSD
  • 2009
Physical Description
  • text
Subjects
Notes
  • BACKGROUND/​AIMS: Longer exposure to hepatitis C (HCV) or B virus (HBV) and the increased use of hepatitis treatment might have an impact on liver-related deaths in patients co-infected with the Human Immunodeficiency Virus (HIV). We describe the proportion of liver-related deaths among HIV-infected patients in 2005 compared with 2000. METHODS: In a nationwide survey (341 hospital departments involved in HIV management), all deaths of HIV-infected patients were prospectively reported. Deaths from either cirrhosis, hepatocellular carcinoma or fulminant hepatitis were defined as liver-related deaths. RESULTS: Of the 898 deaths reported in 2005, liver-related causes accounted for 15.4%; this is compared to 13.4% in 2000. Among liver-related deaths, hepatocellular carcinoma increased from 15% to 25% (p=​0.04). Among hepatocellular carcinoma-related deaths: in 2000, 10% were HCV-infected; in 2005, 25% were HCV-infected (p=​0.03). Half of the HCV-related deaths had been treated for HCV but 98% remained HCV-RNA positive at time of death. The proportion of HBV-related deaths remained stable between 2000 and 2005. CONCLUSIONS: Liver-related deaths, mainly liver cancers, have increased in HIV-infected patients in France despite wide access to HCV treatment. The stability of HBV-related deaths might be explained by the use of dually active antiretroviral drugs in co-infected patients.
  • HAL:inserm-00337886, version 1
  • HAL:http:/​/​www.hal.inserm.fr/​inserm-00337886/​en/​
  • PUBMED:19231018
  • DOI:10.1016/​j.jhep.2008.11.018
Language
  • English
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