2008, English, Article edition: Transmission of HIV-1 minority-resistant variants and response to first-line antiretroviral therapy. Peuchant, Olivia; Thiébaut, Rodolphe; Capdepont, Sophie; ...

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Bookmark: http://trove.nla.gov.au/version/200979
Physical Description
  • text
Published
  • HAL - CCSD
  • 2008
Language
  • English

Edition details

Title
  • Transmission of HIV-1 minority-resistant variants and response to first-line antiretroviral therapy.
Author
  • Peuchant, Olivia
  • Thiébaut, Rodolphe
  • Capdepont, Sophie
  • Lavignolle-Aurillac, Valerie
  • Neau, Didier
  • Morlat, Philippe
  • Dabis, François
  • Fleury, Hervé
  • Masquelier, Bernard
Published
  • HAL - CCSD
  • 2008
Physical Description
  • text
Subjects
Notes
  • BACKGROUND: The transmission of drug-resistant HIV-1 can impair the virological response to antiretroviral therapy. Minority-resistant variants have been detected in acute seroconverters. We investigated the clinical relevance of the detection of majority and minority-resistant variants in an observational study in antiretroviral therapy naive, recently infected patients. METHODS: We included patients infected between 1996 and 2005, with a plasma sample obtained less than 18 months after seroconversion and prior to antiretroviral therapy initiation. Majority-resistant variants were determined by direct population sequencing. Minority-resistant variants were searched by allele-specific PCR for the mutations K103N and M184V in reverse transcriptase and L90M in protease. The association between resistance and viroimmunological response to antiretroviral therapy was estimated by using a piecewise linear mixed model. RESULTS: Majority-resistant variants were detected in 23/​172 (13.4%) patients. Patients with majority-resistant variants had a lower mean plasma viral load and higher mean CD4 cell count at baseline compared with those without resistance. The decrease in viral load between 1 and 6 months on antiretroviral therapy was significantly steeper in patients with sensitive viruses compared with those with majority-resistant variants (P =​ 0.029). Minority-resistant variants were detected in 21/​73 (29%) patients with wild-type viruses at sequencing analysis. The presence of minority-resistant variants did not modify baseline viral load and CD4 cell count and did not affect the changes in viral load and CD4 cell count. CONCLUSION: The transmission of majority-resistant variants, but not minority-resistant variants, influenced the response to antiretroviral therapy in this prospective study. The detection of the transmission of minority-resistant variants warrants further clinical validation.
  • HAL:inserm-00270200, version 1
  • HAL:http:/​/​www.hal.inserm.fr/​inserm-00270200/​en/​
  • PUBMED:18614864
  • DOI:10.1097/​QAD.0b013e3283034953
Language
  • English
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