2005, English, Article edition: Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat. Sinniger, Valérie; Mouchet, Patrick; Bonaz, Bruno

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Physical Description
  • text
Published
  • HAL - CCSD
  • 2005
Language
  • English

Edition details

Title
  • Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat.
Author
  • Sinniger, Valérie
  • Mouchet, Patrick
  • Bonaz, Bruno
Published
  • HAL - CCSD
  • 2005
Physical Description
  • text
Subjects
Notes
  • Nor-trimebutine is the main metabolite of trimebutine that is used in the treatment of patients with irritable bowel syndrome. Nor-trimebutine has a blocking activity on sodium channels and a potent local anesthetic effect. These properties were used to investigate the effect of nor-trimebutine on spinal neuronal activation induced by models of noxious somato-visceral stimulus and acute colonic inflammation. Nor-trimebutine was administered in rats either subcutaneously 30 min before intraperitoneal administration of acetic acid or intracolonically 30 min before intracolonic infusion of trinitrobenzenesulfonic acid. Abdominal contractions were counted for 1 h as a marker of abdominal pain. c-fos expression was used as a marker of neuronal activation and revealed by immunohistochemistry 1h after intraperitoneal acetic acid injection and 2 h after colonic inflammation. Nor-trimebutine decreased Fos expression in the thoraco-lumbar (peritoneal irritation) and lumbo-sacral (colonic inflammation) spinal cord in laminae I, IIo V, VII and X. This effect was also observed in the sacral parasympathetic nucleus after colonic inflammation. Nor-trimebutine induced a significant decrease of abdominal contractions following intraperitoneal acetic acid injection. These data may explain the effectiveness of trimebutine in the therapy of abdominal pain in the irritable bowel syndrome.
  • HAL:inserm-00388054, version 1
  • HAL:http:/​/​www.hal.inserm.fr/​inserm-00388054/​en/​
  • PUBMED:15978629
  • DOI:10.1016/​j.lfs.2005.05.030
Language
  • English
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