2007, English, Article edition: Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line. Platet, Nadine; Mayol, Jean-François; Berger, François; ...

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Bookmark: http://trove.nla.gov.au/version/200413
Physical Description
  • text
Published
  • HAL - CCSD
  • 2007
Language
  • English

Edition details

Title
  • Fluctuation of the SP/​non-SP phenotype in the C6 glioma cell line.
Author
  • Platet, Nadine
  • Mayol, Jean-François
  • Berger, François
  • Hérodin, Francis
  • Wion, Didier
Published
  • HAL - CCSD
  • 2007
Physical Description
  • text
Subjects
Notes
  • Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells.
  • HAL:inserm-00383790, version 1
  • HAL:http:/​/​www.hal.inserm.fr/​inserm-00383790/​en/​
  • PUBMED:17362939
  • DOI:10.1016/​j.febslet.2007.02.071
Language
  • English
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