2001, English, Article edition: Mitochondria in human offspring derived from ooplasmic transplantation: Brief communication Barritt, Jason A.; Brenner, Carol A.; Malter, Henry E.; ...

User activity

Share to:
 
Bookmark: http://trove.nla.gov.au/version/200152
Physical Description
  • text/​html
Published
  • Oxford University Press
  • 2001-03-01 00:00:00.0
Language
  • English

Edition details

Title
  • Mitochondria in human offspring derived from ooplasmic transplantation: Brief communication
Author
  • Barritt, Jason A.
  • Brenner, Carol A.
  • Malter, Henry E.
  • Cohen, Jacques
Published
  • Oxford University Press
  • 2001-03-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • Ooplasmic transfer from fertile donor oocytes into potentially compromised recipient patient oocytes has led to the birth of nearly 30 babies worldwide. Cytoplasmic transplantation has caused apprehension, since the mixing of human ooplasm from two different maternal sources may generate mitochondrial (mt) heteroplasmy (both recipient and donor mtDNA) in offspring. This investigation traced the mitochondrial donor population both during the ooplasmic transfer technique and in the bloods of two 1 year old children using mtDNA fingerprinting. Donor ooplasm stained for active mitochondria was transferred into recipient ooplasm and the mitochondria were visualized by confocal microscopy after the microinjection procedure and fertilization. Heteroplasmy was found in the blood from each of the children. This report is the first case of human germline genetic modification resulting in normal healthy children.
Terms of Use
  • Copyright (C) 2001, European Society of Human Reproduction and Embryology
Language
  • English
Contributed by
OAIster

Get this edition

  • Set up My libraries

    How do I set up "My libraries"?

    In order to set up a list of libraries that you have access to, you must first login or sign up. Then set up a personal list of libraries from your profile page by clicking on your user name at the top right of any screen.

  • All (1)
  • Unknown (1)
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.
None of your libraries hold this item.

User activity


e.g. test cricket, Perth (WA), "Parkes, Henry"

Separate different tags with a comma. To include a comma in your tag, surround the tag with double quotes.

Be the first to add a tag for this edition

Be the first to add this to a list

Comments and reviews

What are comments? Add a comment

No user comments or reviews for this version

Add a comment