2001, English, Article edition: Increased adhesiveness and internalization of Neisseria gonorrhoeae and changes in the expression of epithelial gonococcal receptors in the Fallopian tube of copper T and Norplant(R) users Fernandez, R.; Nelson, P.; Delgado, J.; ...

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Physical Description
  • text/​html
Published
  • Oxford University Press
  • 2001-03-01 00:00:00.0
Language
  • English

Edition details

Title
  • Increased adhesiveness and internalization of Neisseria gonorrhoeae and changes in the expression of epithelial gonococcal receptors in the Fallopian tube of copper T and Norplant(R) users
Author
  • Fernandez, R.
  • Nelson, P.
  • Delgado, J.
  • Aguilera, J.
  • Massai, R.
  • Velasquez, L.
  • Imarai, M.
  • Croxatto, H.B.
  • Cardenas, H.
Published
  • Oxford University Press
  • 2001-03-01 00:00:00.0
Physical Description
  • text/​html
Subjects
Notes
  • Interaction of Neisseria gonorrhoeae with the oviductal epithelium in vitro was examined in 2 cm length segments obtained after surgical sterilization from users of copper T intrauterine device (IUD) or Norplant® and control women. Segments perfused with N . gonorrhoeae suspensions were incubated from 30 min up to 4 h, fixed, frozen and cut in 6–10 μm sections. Bacteria were detected immunohistochemically with rabbit anti-gonococcal serum followed by light and confocal microscopy. Adhesion and internalization of gonococci by epithelial cells were observed at all incubation times, and both were higher in explants from users of copper T IUD or Norplant implants than controls. The epithelium of controls expressed CD66 and syndecan-1; but CD46 was found in only one out of six cases. The epithelium of copper T IUD users expressed CD66 but not syndecan-1 or CD46. Users of Norplant® exhibited expression of CD46, CD66 and syndecan-1. Label was always found along the luminal border of the epithelium. There were more intraepithelial lymphocytes in users of contraceptive methods than in controls. Results indicate that (i) N . gonorrhoeae invade the oviductal epithelium from the first minutes of exposure, (ii) the epithelium is constitutively endowed with two known receptors for the gonococcus, CD66 and syndecan-1, (iii) copper T IUD and Norplant users exhibit higher rates of attachment and internalization of the gonococcus into the oviductal epithelium associated with changes in expression of gonococcal receptors.
Terms of Use
  • Copyright (C) 2001, European Society of Human Reproduction and Embryology
Language
  • English
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